Evidence map›Paper›PMID 41408988›Full record

ArticleArthritis care & research2026

Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over.

Amanda J Rickard, Cammie Tran, Hans G Schneider, Flavia M Cicuttini, Anita E Wluka, Ego Seeman, Johannes T Neumann, Md Nazmul Karim, Zhen Zhou, Sultana Monira Hussain and 6 more

Abstract read
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In one paragraph

Article in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Amanda J RickardMonash University, Melbourne, Australia.ORCID 0009-0001-5774-1219
Cammie TranMonash University, Melbourne, Australia.
Hans G SchneiderMonash University and The Alfred Hospital, Melbourne, Australia.
Flavia M CicuttiniMonash University, Melbourne, Australia.ORCID 0000-0002-8200-1618
Anita E WlukaMonash University, Melbourne, Australia.ORCID 0000-0001-8024-9049
Ego SeemanUniversity of Melbourne, Melbourne, Australia.
Johannes T NeumannMonash University, Melbourne, Australia, and University Heart & Vascular Centre, Hamburg, Germany.
Md Nazmul KarimMonash University, Melbourne, Australia.
Zhen ZhouMonash University, Melbourne, Australia.
Sultana Monira HussainMonash University and University of Melbourne, Melbourne, Australia.ORCID 0000-0001-7894-2485
David P Q ClarkMonash University, Melbourne, Australia.
Daniel Clayton-ChubbMonash University and The Alfred Hospital, Melbourne, Australia.
Andrew M TonkinMonash University, Melbourne, Australia.
Lawrence J BeilinUniversity of Western Australia, Perth, Australia.
Robyn L WoodsMonash University, Melbourne, Australia.
John J McNeilMonash University, Melbourne, Australia.

Funding

Abbott DiagnosticsAlfred HealthAlfred Pathology serviceAustralian Government's Commonwealth Scientific and Industrial Research Organisation (Preventative Health Flagship 2009)Monash UniversityNational Cancer Institute/National Institutes of Health 5U01AG029824-02National Health and Medical Research Council 1127060National Health and Medical Research Council 334047National Institute on Aging and the National Cancer Institute at the National Institutes of Health U01AG029824National Institute on Aging and the National Cancer Institute at the National Institutes of Health U19AG062682
6 · The paper itself

Abstract

objectiveReports have linked both high and low serum uric acid (SUA) levels to adverse health outcomes. This study aimed to establish a reference interval for SUA in older adults and assessed its association with clinically relevant outcomes in relatively healthy, community-dwelling individuals aged ≥70 years old.

methodsThe study used data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. In Australia, 11,878 ASPREE participants had baseline SUA measurements (median age 74 years old). The study sample (n = 11,446; 55% women) comprised individuals with baseline SUA measurements, excluding those on urate-lowering medication. The reference sample (n = 10,501; 55% women) was established after further exclusion of participants with impaired renal function, defined as an estimated glomerular filtration rate <45 mL/min/1.73m

resultsSUA reference intervals were 0.24 to 0.54 mmol/L for men and 0.19 to 0.48 mmol/L for women. After adjusting for potential confounders, no association was observed between SUA levels and all-cause mortality, disability-free survival, cardiovascular disease, major adverse cardiovascular events, cancer incidence and mortality, or dementia in either the study or reference samples. In women, however, low SUA levels were associated with an increased risk of fractures (hazard ratio 1.23; 95% confidence interval 1.04-1.46).

conclusionAlthough previous reports have linked abnormal SUA levels to adverse health outcomes, our findings show no associations within the reference range, except for an increased fracture risk among women with low SUA levels.

Indexed as

Uric AcidAgedAged, 80 and overAge FactorsAustraliaBiomarkersFemaleHumansMaleReference ValuesRisk FactorsBiomarkersUric Acid

Identifiers

PMID41408988
PMCPMC12975696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.