Evidence map›Paper›PMID 41408964›Full record

ArticleEpilepsia2026

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease.

Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra-Puerta, Nerea Iglesias-Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo and 8 more

Abstract read
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In one paragraph

Article in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Cinzia CostaSection of Neurophysiopathology S.M. della Misericordia Hospital, Section of Neurology and Laboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID https://orcid.org/0000-0002-4862-4221
Laura BellingacciSection of Physiology and Biochemistry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Jacopo CanonichesiLaboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Valentina ImperatoreLaboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Anna Aurora TaddeiLaboratory of Experimental Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.ORCID https://orcid.org/0009-0002-6731-2343
Luis Zafra-PuertaLaboratory of Neurology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.ORCID https://orcid.org/0000-0002-1807-7538
Nerea Iglesias-CabezaLaboratory of Neurology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.
Paolo PronteraMedical Genetics and Rare Diseases Unit, Maternal-Infantile Department, S.M. Della Misericordia Hospital, Perugia, Italy.
Andrea ManciniSection of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Massimiliano Di FilippoSection of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Alessandro TozziSection of Physiology and Biochemistry, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Katiuscia MartinelloIstituto Neurologico Mediterraneo Pozzilli (Neuromed) - Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Pozzilli, Italy.
Marta BarzasiDepartment of Pharmacological and Biomolecular Sciences, University of Milano, Milan, Italy.
Fabrizio GardoniDepartment of Pharmacological and Biomolecular Sciences, University of Milano, Milan, Italy.
Marina P SánchezLaboratory of Neurology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.
José M SerratosaLaboratory of Neurology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.
Lucilla ParnettiSection of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Miriam SciaccalugaFondazione Malattie Rare Mauro Baschirotto BIRD Onlus, Longare, Italy.ORCID https://orcid.org/0000-0001-7951-8045

Funding

AEVEL FoundationAssociazione Stella Costa di AmalfiCentro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) 23 - U744Fondazione Malattie Rare Mauro Baschirotto BIRD OnlusItalian Ministry of University and Research 2022CAKAHLItalian Ministry of University and Research P2022374Y9Ministero della Salute PNRR-MR1-2022-12376430National Institute of Neurological Disorders and Stroke of the National Institutes of Health P01NS097197Spanish Ministry of Economy Rti2018-095784b-100SAF MCI/AEI/FEDERTatiana Pérez de Guzmán el Bueno Foundation
6 · The paper itself

Abstract

BACKGROUND AND

objectiveLafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug-resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG) of the Epm2a

methodsElectrophysiological recordings measured neuronal membrane properties, epileptic-like activity, epileptic thresholds, and synaptic plasticity in Epm2a

resultsEpileptic-like activity began at 1 month and intensified with age. Aberrant long-term potentiation (LTP) appeared at 3 months and worsened by 12 months. Notably, cannabidiol treatment reduced excitability and restored LTP in older mice, suggesting its potential therapeutic value. SIGNIFICANCE: The reversibility of synaptopathy, even at advanced stages, reinforces the importance of early detection of hyperexcitability and the development of effective therapeutic approaches.

Indexed as

HippocampusLafora DiseaseNeuronsSynapsesAnimalsDentate GyrusDisease Models, AnimalGene Knock-In TechniquesLong-Term PotentiationMaleMiceMice, Inbred C57BLMice, TransgenicProtein Tyrosine Phosphatases, Non-ReceptorUbiquitin-Protein LigasesEpm2a protein, mouseProtein Tyrosine Phosphatases, Non-ReceptorUbiquitin-Protein Ligasescannabidiolhippocampal synaptic dysfunctionLafora diseaseneuronal hyperexcitabilitysynaptic plasticity

Identifiers

PMID41408964
PMCPMC13007839

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.