ArticleJournal of cosmetic dermatology2025
The Combination of Pterocarpus marsupium Bark Extract, Pinus strobus Bark Extract, and Ascorbyl Tetraisopalmitate Inhibits Melanogenesis via Nicotinamide Nucleotide Transhydrogenase Activation.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
Abstract
backgroundExcessive ultraviolet exposure triggers skin pigment deposition, potentially leading to conditions such as melasma, freckles, and post-inflammatory hyperpigmentation. The skin of individuals with these dermatological conditions exhibits reduced levels of nicotinamide nucleotide transhydrogenase (NNT). While many seek skin-whitening products to address pigmentation, existing options often fail to achieve optimal efficacy. To accomplish a synergistic whitening effect, we developed PPV, a composite formulation incorporating three depigmenting agents: Pterocarpus marsupium bark extract (PMBE), Pinus strobus bark extract (PSBE), and ascorbyl tetraisopalmitate (VC-IP).
aimsThis study aimed to investigate the effects of PPV on skin whitening and elucidate its mechanisms.
methodsAfter administering PPV to B16F10 melanoma cells, we measured melanin content and gene expression of TYR, TRP-1, and TRP-2 using a microplate reader and qPCR. Western blotting was used to assess p-CREB, CREB, MITF, and NNT expression. The Jin's formula was used to evaluate the combined effect of the three components of PPV on NNT at the genetic level. Oxidative stress levels were evaluated with ROS, GSH/GSSG, and NADP
resultsPPV significantly influenced melanin production in melanocytes and human ex vivo skin. This effect was due to the inhibitory effect of PPV on the CREB-MITF signaling pathway and the synergistic activation effect of PMBE, PSBE, and VC-IP on the NNT gene expression in B16F10 cells. Activation of NNT led to a reduction in ROS levels and the NADP
conclusionPPV, synthesized from PMBE, PSBE, and VC-IP, exhibited an anti-melanogenic effect. This effect was attributed to the inhibition of CREB-MITF-mediated melanogenesis and the regulation of oxidative stress by NNT. The findings suggest PPV as a potential therapeutic agent for skin pigmentation disorders.
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