Evidence map›Paper›PMID 41408829›Full record

ArticleActa biochimica et biophysica Sinica2025

Fructose uptake by brown adipose tissue is independent of carbohydrate response element-binding protein and does not cause elevated

Janina Behrens, Marceline Manka Fuh, Daniel T Haas, Michelle Y Jaeckstein, Markus Heine, Bente Siebels, Anna Worthmann, Natalie Krahmer, Joerg Heeren, Ludger Scheja

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In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Janina BehrensDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Marceline Manka FuhDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Daniel T HaasInstitute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Munich, 85764, Neuherberg, Germany; German Center for Diabetes Research (DZD), Helmholtz Munich, 85764, Neuherberg, Germany.
Michelle Y JaecksteinDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Markus HeineDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Bente SiebelsSection Mass Spectrometry and Proteomics, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Anna WorthmannDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Natalie KrahmerInstitute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Munich, 85764, Neuherberg, Germany; German Center for Diabetes Research (DZD), Helmholtz Munich, 85764, Neuherberg, Germany.
Joerg HeerenDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Ludger SchejaDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brown adipose tissue (BAT) is a heat-generating organ burning significant amounts of calories from fatty acids and glucose. The importance of glucose metabolism in the context of thermogenic function has been underlined by several studies. However, fructose metabolism and consequences of fructose overfeeding are poorly studied in BAT. Here we provide evidence that brown adipocytes use fructose as a substrate, however to a lesser extent than glucose. Furthermore, our data suggest that carbohydrate response element binding protein (ChREBP) and its target glucose transporter 5 (GLUT5) are not essential for fructose uptake and metabolism in BAT. Notably, we report that high fructose feeding has no effect on ChREBP activity and thus

Indexed as

Adipose Tissue, BrownBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsFructoseLipogenesisNuclear ProteinsTranscription FactorsAdipocytes, BrownAnimalsGlucoseGlucose Transporter Type 5MaleMiceMice, Inbred C57BLBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsFructoseGlucoseGlucose Transporter Type 5Mlxipl protein, mouseNuclear ProteinsSlc2a5 protein, mouseTranscription Factorsbrown adipose tissueceramidesChREBPfructoselipogenesis

Identifiers

PMID41408829
PMCPMC13449002

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.