Evidence map›Paper›PMID 41408751›Full record

ArticleBiophysical journal2026

Arrhythmia risk predictions from molecular simulations of cardiac ion channel-drug interactions.

Kyle C Rouen, Kush Narang, Yanxiao Han, David Wang, Ensley Jang, Sophia Brunkow, Vladimir Yarov-Yarovoy, Alexander D MacKerell, Igor Vorobyov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyle C RouenDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, California. Electronic address: kcrouen@ucdavis.edu.
Kush NarangDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, California.
Yanxiao HanDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, California; Department of Biological Sciences, University of North Texas, Denton, Texas.
David WangDepartment of Surgery, University of California, Davis, Davis, California; Department of Biomedical Engineering, University of California, Davis, Davis, California.
Ensley JangDepartment of Chemistry, University of California, Davis, Davis, California.
Sophia BrunkowDepartment of Chemistry, University of California, Davis, Davis, California.
Vladimir Yarov-YarovoyDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, California; Department of Anesthesiology and Pain Medicine, University of California, Davis, Davis, California; Center for Precision Medicine and Data Sciences, University of California, Davis, Davis, California.
Alexander D MacKerellDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland. Electronic address: alex@outerbanks.umaryland.edu.
Igor VorobyovDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, California; Department of Pharmacology, University of California, Davis, Davis, California. Electronic address: ivorobyov@ucdavis.edu.

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Macromolecular Conformational HeterogeneityR35GM131710 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI ALEXANDER D MACKERELL · 2019 to 2026
$6.2M
Development of the Predictive NeuroCardiovascular SimulatorOT2OD026580 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, GRANDI, ELEONORA · 2018 to 2021
$5.7M
In silico Safety PharmacologyR01HL128537 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2016 to 2024
$5.7M
Predictive multiscale in silico cardio-pharmacologyU01HL126273 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E · 2015 to 2019
$3.8M
Multi-Scale Modeling of Vascular Signaling UnitsR01HL152681 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CLANCY, COLLEEN E, SANTANA, LUIS F · 2020 to 2023
$2.4M
Digital Twins from the Atom to the RhythmR01HL174001 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COLLEEN E CLANCY, Luis F Santana · 2024 to 2026
$2.4M
UC Davis Training Program in Chemical BiologyT32GM136597 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SHEILA Sue DAVID, Marie C. Heffern · 2021 to 2026
$1.7M
Investigation of state-specific drug binding to cardiac ion channels to reveals mechanisms of arrhythmogenesisF31HL174025 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ROUEN, KYLE C · 2024 to 2025
$84k
NHLBI NIH HHS F31 HL174025NHLBI NIH HHS R01 HL128537NHLBI NIH HHS R01 HL152681NHLBI NIH HHS R01 HL174001NHLBI NIH HHS T32 HL086350NHLBI NIH HHS U01 HL126273NIGMS NIH HHS R35 GM131710NIGMS NIH HHS T32 GM136597NIH HHS OT2 OD026580
6 · The paper itself

Abstract

Unintended block of cardiac ion channels, particularly hERG (K

Indexed as

Arrhythmias, CardiacCalcium Channels, L-TypeERG1 Potassium ChannelMolecular Docking SimulationBayes TheoremHumansMachine LearningNAV1.5 Voltage-Gated Sodium ChannelProtein BindingCalcium Channels, L-TypeERG1 Potassium ChannelL-type calcium channel alpha(1C)NAV1.5 Voltage-Gated Sodium Channel

Identifiers

PMID41408751
PMCPMC13507445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.