Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
34 authors.
Solia AdriouchSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.
Eugeni BeldaSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0003-4307-5072
Timothy D SwartzIntegrative Phenomics, Paris, France.
Sofia ForslundCharité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-4285-6993
Edi PriftiSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0001-8861-1305
Judith Aron-WisnewskySorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0002-3104-9769
Rima ChakarounWallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-9901-1815
Trine NielsenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen.ORCID 0000-0002-2066-7895
Christine PoitouSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0001-7769-6331
Pierre Bel-LassenSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0002-8085-2881
Christine RouaultSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.
Tiphaine Le RoySorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.
Petros AndrikopoulosDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-1555-3498
Kanta ChechiDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0003-1929-4128
Francesc Puig-CastellvíEGENODIA Inserm U1283, CNRS UMR8199, Institut Pasteur de Lille, Lille University Hospital, European Genomic Institute for Diabetes (EGID), Université de Lille, Lille, France.ORCID 0000-0003-1064-9586
Inés Castro DionicioEGENODIA Inserm U1283, CNRS UMR8199, Institut Pasteur de Lille, Lille University Hospital, European Genomic Institute for Diabetes (EGID), Université de Lille, Lille, France.ORCID 0000-0003-4349-3477
Philippe FroguelDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0003-2972-0784
Rohia AliliSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.
Fabrizio AndreelliSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0002-1207-3624
Hedi SoulaSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0001-5306-9712
Joe-Elie SalemAssistance Publique - Hôpitaux de Paris (AP-HP), Clinical Investigation Center (CIC-1901), Department of Pharmacology, Pitié-Salpêtrière Hospital,Sorbonne Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.ORCID 0000-0002-0331-3307
Gwen FalonyHost Microbe Interactomics Group, Wageningen University & Research, Wageningen, The Netherlands.
Sara Vieira-SilvaInstitute of Medical Microbiology and Hygiene and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.ORCID 0000-0002-4616-7602
Peer BorkStructural and Computational Biology Unit, EMBL, Heidelberg, Germany.ORCID 0000-0002-2627-833X
Michael StumvollMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.ORCID 0000-0001-6225-8240
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen.ORCID 0000-0002-3321-3972
S Dusko EhrlichDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0002-7563-4046
Marc-Emmanuel DumasDivision of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-9523-7024
Jean-Michel OppertAssistance Publique - Hopitaux de Paris, Department of Nutrition, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.ORCID 0000-0003-0324-4820
Maria Carlota DaoDepartment of Agriculture, Nutrition, and Food Systems, University of New Hampshire, Durham, NH, USA.ORCID 0000-0001-6284-7352
Jean-Daniel ZuckerSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0002-5597-7922
Karine ClémentSorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Paris, France.ORCID 0000-0002-2489-3355
Funding
Wellcome Trust
6 · The paper itself
Abstract
Lifestyle factors influence both gut microbiome composition and host metabolism, yet their combined and mediating effects on host phenotypes remain poorly characterized in cardiometabolic populations. In 1,643 participants from the MetaCardis study, we developed a composite lifestyle score (QASD: dietary quality, physical activity, smoking, and diet diversity) that outperformed individual lifestyle variables in explaining microbial gene richness and exhibited a significant impact on the gut microbiome composition. While bidirectional pathways linking the QASD score, host phenotypes, and microbiome composition were assessed, causal inference-based mediation analyses indicated stronger effects when the microbiome was modeled as the mediator variable, particularly in relation to the insulin resistance-associated profile. Microbiome gene richness emerged as a key mediator explaining 27.8% of QASD score's effect on the insulin resistance marker (HOMA-IR), while no significant mediation was observed on BMI. Extended mediation analyses on microbial species and serum metabolomics deconfounded for drug use and clinical profiles identified 47 mediations where microbial taxa mediated more than 20% of the effect of the QASD score on serum metabolites associated with insulin resistance. Notably, several
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes. · full record | OpenQuestion