Evidence map›Paper›PMID 41408507›Full record

Observational studyBMC anesthesiology2025

Evaluation of high flow nasal cannulae during endobronchial ultrasound bronchoscopy (EBUS) in high anaesthetic risk patients: a monocentric prospective study.

Pasquale De Vico, Lavinia Aluisantonio, Stefano Verri, Sara Peruzzi, Paola Rogliani, Mario Dauri, Ermanno Puxeddu

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pasquale De VicoDepartment of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Oxford St N. 81, Rome, 00133, Italy. devico.p@gmail.com.
Lavinia AluisantonioEmergency Department, University of Rome Tor Vergata, Oxford St N. 81, Rome, 00133, Italy.
Stefano VerriUnit of Respiratory Medicine, Department of Experimental Medicine, University of Rome Tor Vergata, Oxford St N. 81, Rome, 00133, Italy.
Sara PeruzziEmergency Department, University of Rome Tor Vergata, Oxford St N. 81, Rome, 00133, Italy.
Paola RoglianiUnit of Respiratory Medicine, Department of Experimental Medicine, University of Rome Tor Vergata, Oxford St N. 81, Rome, 00133, Italy.
Mario DauriDepartment of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Oxford St N. 81, Rome, 00133, Italy.
Ermanno PuxedduUnit of Respiratory Medicine, Department of Experimental Medicine, University of Rome Tor Vergata, Oxford St N. 81, Rome, 00133, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoBronchial UltraSound-guided TransBronchial Needle Aspiration (EBUS-TBNA) is a widely used technique in pulmonary diseases. The procedure may lead to respiratory complications that affect patient's clinical status, especially in the presence of pre-existing comorbidities. The aim of this observational study is to investigate the effectiveness of oxygen therapy administered by high flow nasal cannulae (HFNC) in this setting.

methodsStudy population comprised 40 consecutive patients with high anaesthetic risk (ASA III) who underwent EBUS-TBNA at the Tor Vergata University Hospital of Rome. 20 patients were oxygenated with standard low-flow system and 20 patients with HFNC. All patients underwent deep sedation with a combination of midazolam + propofol.

resultsHFNC treated patients showed significant smaller drop in O2 saturation compared to standard oxygen group (3.8 ± 5.9 vs 12.3 ± 15.3, 95% CI 0.91 to 16.14, P = 0.029). Furthermore, the lowest O2 saturation in the control group was significantly lower (83.2 ± 15.6 vs 91.4 ± 5.9, 95% CI -15.86 to -0.35, P = 0.041) requiring a higher FiO2 (oxygen fraction) increase compared to HFNC group (7.7 ± 9.7 vs 2.1 ± 6.3, 95% CI 26.16 to 66.84, P = 0.043). Episodes of desaturation were shorter in the HFNC group (90 ± 37.9 s. vs 120 ± 39.2 s., 95% CI 26.16 to 66.84, P = 0.040).

conclusionsOur results support HFNC as an effective tool to limit the severity of episodes of desaturation and hypoxia. The innovation of this work is represented by the use of HFNC in a population of complex patients at high anaesthetic risk.

Indexed as

BronchoscopyCannulaEndoscopic Ultrasound-Guided Fine Needle AspirationOxygen Inhalation TherapyAgedDeep SedationFemaleHumansMaleMidazolamMiddle AgedProspective StudiesMidazolamAnaesthetic riskBronchoscopyEBUS-TBNAHFNCSedation

Identifiers

PMID41408507
PMCPMC12853666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.