ArticleAnnals of medicine2025
Elevated serum NLRP3 inflammasome level potentially predicts haemorrhagic transformation and unfavourable outcome in acute ischemic stroke patients.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- LncRNA HOTAIR/miR-9-5p/FOXP1 axis modulates cerebral ischemia-reperfusion injury via NLRP3 inflammasome activation.IBRO neuroscience reports · 2026Article
- Stratified Efficacy and Peripheral Neuroinflammatory Mechanisms of Jin's Tongue Triple Acupuncture as Adjunctive Therapy for Subacute Post-Stroke Broca Aphasia: A 1:1 PSM Retrospective Cohort Study.Journal of molecular neuroscience : MN · 2026Article
- Inflammation-centered neurovascular-immune-metabolic remodeling in ischemic stroke: stage-dependent mechanisms, regulated cell death, and therapeutic translation.Frontiers in immunology · 2026Review
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5 authors.
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Abstract
objectiveTo assess the diagnostic value of serum NLRP3 inflammasome and occludin levels in predicting hemorrhagic transformation (HT) and functional outcomes in acute ischemic stroke (AIS).
methodsAIS patients and matched controls were enrolled between June and November 2021. Serum biomarkers were measured and correlated with infarct volume, stroke severity, HT occurrence, and prognosis. Predictive performance was evaluated using logistic regression and ROC curves.
resultsA total of 156 AIS patients and 55 controls were included. AIS patients showed significantly elevated serum NLRP3 (56.59 pg/mL vs. 33.24 pg/mL) and occludin levels (97.42 ng/mL vs. 44.54 ng/mL) (both
conclusionsElevated serum NLRP3 inflammasome levels represent a promising biomarker for predicting HT and unfavorable outcomes in AIS patients.
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