Evidence map›Paper›PMID 41408334›Full record

ArticleJournal of ovarian research2025

Integrative analysis and experiments to explore GAS1 as a prognostic target for ovarian cancer based on angiogenesis-related genes.

Lingyun Zhai, Da Huang, Liya Lin, Ruqian Zheng, Qionghua He, Xiaoqing Zhu, Rui Liu, Jing Fei, Zhigang Zhang, Xiaoming Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lingyun ZhaiDepartment of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Da HuangDepartment of Basic Medicine Sciences, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Liya LinBasic and Translational Research Center, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Ruqian ZhengDepartment of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Qionghua HeDepartment of Gynecology and Obstetrics, the First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.
Xiaoqing ZhuDepartment of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Rui LiuDepartment of Basic Medicine Sciences, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Jing FeiDepartment of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Zhigang ZhangDepartment of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xiaoming ZhangDepartment of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. zxm@zju.edu.cn.
Jianwei ZhouDepartment of Gynecology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. jianwei-zhou@zju.edu.cn.

Funding

the National Natural Science Foundation of China 32471290
6 · The paper itself

Abstract

backgroundIntratumoral angiogenesis is crucial for the proliferation and metastasis of ovarian cancer. This study aims to comprehensively analyze the impact of angiogenesis-related genes on clinical outcomes, the immune landscape, and immunotherapy response in ovarian cancer.

resultsThrough integrated analysis of transcriptomic data from The Cancer Genome Atlas and Gene Expression Omnibus databases, we identified two novel angiogenesis subtypes that exhibited significant differences in clinicopathological features, prognostic outcomes, and tumor microenvironment characteristics. An angiogenesis-based risk score was developed, which effectively stratified patients into distinct risk groups. These groups demonstrated divergent clinical prognosis, immune cell infiltration patterns, expression levels of immune checkpoint genes, and sensitivity to chemotherapeutic agents. Furthermore, growth arrest-specific 1 was validated as a hub prognostic gene, showing abnormal expression in ovarian cancer tissues. Functional experiments confirmed that upregulation of growth arrest-specific 1 significantly suppressed the proliferative and migratory capacities of ovarian cancer cells.

conclusionsOur findings underscore the integral relationship between angiogenesis and the immune microenvironment in ovarian cancer. The angiogenesis-based risk score provides a promising prognostic tool, and growth arrest-specific 1 is implicated as a potential diagnostic and prognostic biomarker for ovarian cancer patients.

Indexed as

Neovascularization, PathologicOvarian NeoplasmsAngiogenesisBiomarkers, TumorCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansPrognosisTumor MicroenvironmentBiomarkers, TumorAngiogenesisGrowth arrest-specific 1ImmunotherapyOvarian cancerTumor microenvironment

Identifiers

PMID41408334
PMCPMC12822331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.