Trial reportNutrition journal2025
Associations and predictive value of weight-adjusted waist index for cardiovascular outcomes in type 2 diabetes: evidence from the ACCORD study.
Trial report in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000620. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Action to Control Cardiovascular Risk in Diabetes (ACCORD)
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study aimed to investigate the association between the weight-adjusted waist circumference index (WWI) and cardiovascular outcomes in patients with T2DM.
methodsUsing Cox proportional hazards regression models to determine the impact of WWI on cardiovascular event. Nonlinear associations were explored through restricted cubic splines (RCS) and smooth curve fitting (SCF), and the integrity of these findings was supported by subgroup and sensitivity analyses.
resultsAn elevation in WWI was linked to a significant rise in the likelihood of major adverse cardiovascular events (MACEs), composite cardiovascular outcomes MSD, including myocardial infarction, stroke, and any death, congestive heart failure (CHF), and total mortality (TM). An increase of per 1 standard deviations (SD) in WWI corresponded to a 7% heightened risk of MACEs (HR: 1.07, 95% CI: 1.02, 1.13), a 9% greater risk of MSD (HR: 1.09, 95% CI: 1.04, 1.13), a 20% greater risk of CHF (HR: 1.20, 95% CI: 1.10, 1.30), and a 11% increase in TM (HR: 1.11, 95% CI: 1.06, 1.17). RCS and SCF analysis revealed a nonlinear correlation between WWI and the risks of CHF and TM. Subgroup analyses demonstrated that WWI more accurately predicted CHF risk in patients whose duration of diabetes was under 10 years. Sensitivity analyses reinforced the reliability of these results.The integration of WWI into conventional predictive models improved the accuracy of these outcomes.
conclusionsWWI is closely associated with future cardiovascular outcomes and TM in patients with T2DM.WWI serves as an autonomous predictor of both future cardiovascular events and TM among patients with T2DM, outperforming traditional obesity indices in predictive ability. CLINICAL TRIAL URLS: https://clinicaltrials.gov/ct2/show/NCT00000620.
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Registered trials
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