Evidence map›Paper›PMID 41408219›Full record

ArticleBMC cancer2025

Association of the YTHDF2 rs3738067 A>G variant with hepatoblastoma risk: a multicenter case-control study in Chinese children.

Zhuo Wang, Jinhong Zhu, Wenli Zhang, Zhonghua Yang, Yong Li, Li Li, Suhong Li, Jiwen Cheng, Jiao Zhang, Jing He and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Zhuo Wang *Department of Pediatric Surgery, Department of Dermatology, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China.
Jinhong Zhu *Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150040, China.
Wenli Zhang *Department of Pediatric Surgery, Department of Dermatology, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China.
Zhonghua YangDepartment of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.
Yong LiDepartment of Pediatric Surgery, Hunan Children's Hospital, Changsha, Hunan, 410004, China.
Li LiKunming Key Laboratory of Children Infection and Immunity, Yunnan Key Laboratory of Children's Major Disease Research, Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children's Hospital, Kunming, Yunnan, 650228, China.
Suhong LiDepartment of Pathology, Children Hospital and Women Health Center of Shanxi, Taiyuan, Shannxi, 030013, China.
Jiwen ChengDepartment of Pediatric Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710004, China.
Jiao ZhangDepartment of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Jing HeDepartment of Pediatric Surgery, Department of Dermatology, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China. hejing198374@gmail.com.ORCID http://orcid.org/0000-0002-1954-2892
Peng YiCenter of Reproductive Medicine, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, 100 Minjiang Road, Quzhou, Zhejiang, 324000, China. yipengqz@163.com.

Funding

Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease 2019B030301004
6 · The paper itself

Abstract

backgroundAs a rare cancer, hepatoblastoma is the most prevalent malignant liver tumor in children, yet its underlying causes are poorly understood. YTHDF2, a canonical m⁶A reader, regulates mRNA stability and decay, and its dysregulation has been implicated in tumorigenesis across multiple malignancies. Whether YTHDF2 polymorphisms influence hepatoblastoma risk is unclear. This multicenter case-control study was therefore designed to analyze the YTHDF2 rs3738067 A > G variant in Chinese children.

methodsWe recruited 313 hepatoblastoma cases and 1446 controls from seven hospitals across China for this case-control study. The YTHDF2 rs3738067 A > G polymorphism was genotyped using the TaqMan PCR method. We assessed its association with hepatoblastoma risk using multivariate logistic regression to calculate adjusted odds ratios and 95% confidence intervals, controlling for age and sex.

resultsComprehensive analyses of this multi-center Chinese pediatric cohort revealed that the YTHDF2 rs3738067 A > G polymorphism was not associated with hepatoblastoma risk in any analysis, including the overall population and all stratified subgroups.

conclusionsThese findings suggest that this specific YTHDF2 variant may not be a key risk factor for hepatoblastoma in Chinese children. Future studies incorporating diverse ethnic populations and investigating other polymorphisms, alone or in combination, are warranted to confirm these findings and explore potential associations.

Indexed as

Genetic Predisposition to DiseaseHepatoblastomaLiver NeoplasmsPolymorphism, Single NucleotideRNA-Binding ProteinsCase-Control StudiesChildChild, PreschoolChinaEast Asian PeopleFemaleGenotypeHumansInfantMaleRisk FactorsRNA-Binding ProteinsYTHDF2 protein, humanHepatoblastomaPolymorphismSusceptibilityYTHDF2

Identifiers

PMID41408219
PMCPMC12822027

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