ArticleBMC geriatrics2025
Synergistic effects of multicomponent exercise and rTMS on sarcopenia and mild cognitive impairment in older people: a protocol for a randomized controlled trial.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
backgroundSarcopenia and cognitive impairment (CI) are major contributors to disability in older people, significantly reducing quality of life and imposing a substantial burden on healthcare systems. Sarcopenia accelerates cognitive decline through mechanisms such as chronic inflammation, mitochondrial dysfunction, and disruption of the muscle-brain axis. Conversely, CI impairs motor planning and daily functioning, further exacerbating muscle loss and physical deterioration. Previous studies have shown that physical exercise optimizes peripheral physiological conditions, promoting neuroplasticity in the central nervous system. Similarly, repetitive transcranial magnetic stimulation (rTMS) enhances brain plasticity, improving both cognitive and physical functions. This study aims to evaluate the combined effects of multicomponent exercise and rTMS on sarcopenia and CI in older people.
methodsThis is a 16-week, randomized, single-blind, controlled trial. A total of 51 older people with sarcopenia and mild cognitive impairment (MCI) will be randomly assigned to one of three groups: (1) exercise combined with rTMS, (2) exercise combined with sham rTMS, and (3) a control group. The exercise intervention will integrate Baduanjin and resistance training, while rTMS will target the dorsolateral prefrontal cortex (DLPFC). Participants will be assessed for muscle fitness, cognitive function, and psychological well-being at baseline, week 8, and week 16. DISCUSSION: This trial aims to provide empirical evidence on the synergistic effects of exercise and rTMS in managing sarcopenia and MCI in older people. Additionally, it will explore the neural mechanisms underlying improvements in cognitive function. The findings may inform integrated treatment strategies for these interconnected conditions, enhancing quality of life and promoting functional independence in aging populations.
trial registrationInternational Traditional Medicine Clinical Trial Registry, ITMCTR2025000311. Registered 17 February 2025.
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