Evidence map›Paper›PMID 41408152›Full record

ArticleBMC genomics2025

Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype.

Benjamin J Hanrahan, J King Chang, Ashley M Milton, Nicholas C Lister, Duminda S B Dissanayake, Jillian M Hammond, Andre L M Reis, Ira W Deveson, Aurora Ruiz-Herrera, Hardip R Patel and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Benjamin J HanrahanEvolution & Ecology Research Centre, School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, 2052, Australia.
J King ChangEvolution & Ecology Research Centre, School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, 2052, Australia.
Ashley M MiltonEvolution & Ecology Research Centre, School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, 2052, Australia.
Nicholas C ListerEvolution & Ecology Research Centre, School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, 2052, Australia.
Duminda S B DissanayakeInstitute for Applied Ecology, University of Canberra, Canberra, ACT, 2601, Australia.
Jillian M HammondGenomics Pillar, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Andre L M ReisGenomics Pillar, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Ira W DevesonGenomics Pillar, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Aurora Ruiz-HerreraDepartament de Biologia Cel·Lular, Fisiologia I Immunologia, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193, Barcelona, Spain.
Hardip R PatelNational Centre for Indigenous Genomics, Australian National University, Canberra, ACT, 2601, Australia.
Jennifer A Marshall GravesInstitute for Applied Ecology, University of Canberra, Canberra, ACT, 2601, Australia.
Arthur GeorgesInstitute for Applied Ecology, University of Canberra, Canberra, ACT, 2601, Australia.
Paul D WatersEvolution & Ecology Research Centre, School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, 2052, Australia. p.waters@unsw.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLizards have sex determination systems that can differ between even closely related species. These include XY and ZW systems, and thermolabile systems where genes and temperature interact to determine sex. The eastern three-lined skink (Bassiana duperreyi) has a differentiated XY sex determination system, in which low temperature incubation during development can cause female to male sex reversal, producing XX males. This provides a unique opportunity to investigate how genotype and sexual phenotype affect dosage compensation.

resultsHere, we present a draft genome assembly of the Eastern three-lined skink generated from nanopore sequencing. We also generated transcriptomes from brain and heart tissue of normal adult males and females, along with brain tissue of sex-reversed XX males. We observed partial dosage compensation between XX females and XY males in both brain and heart, with median gene expression from the X in normal males being 0.7 times that of normal females. In brain of sex reversed XX males the median X chromosome output matched that of the normal XX female level, and not that of normal XY males.

conclusionsPartial dosage compensation in the Eastern three-lined skink is similar to several other species of lizard. However, here for the first time we describe dosage compensation in a lizard with natural sex reversal, and show that in sex reversed individuals dosage compensation of the X chromosome follows genotypic sex and not phenotypic sex.

Indexed as

Dosage Compensation, GeneticLizardsSex ChromosomesSex Determination ProcessesAnimalsFemaleMalePhenotypeTranscriptomeBassiana duperreyiDosage compensationSex chromosomesSex reversal

Identifiers

PMID41408152
PMCPMC12822173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.