Evidence map›Paper›PMID 41408131›Full record

ArticleScientific reports2025

An improved porcine model of infrarenal abdominal aortic aneurysm.

Marta Stei, Per Arkenberg, Theresa Uebing, Agnesa Mazrekaj, Joscha Mulorz, Dennis Mehrkens, Maysam Ahdab, Philipp Barnowski, Gerhard Sengle, Matti Adam and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Marta SteiHeart Center Bonn, Clinic for Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Per ArkenbergHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Theresa UebingDepartment of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Agnesa MazrekajDepartment of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Joscha MulorzDepartment of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Dennis MehrkensHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Maysam AhdabHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Philipp BarnowskiCenter for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Gerhard SengleCenter for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Matti AdamHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Valerie LohnerCardiovascular Epidemiology of Aging, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Verena HoerrHeart Center Bonn, Clinic for Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Ali NahardaniHeart Center Bonn, Clinic for Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Claudia Schubert-QueckeExperimental Medicine, University Hospital of Cologne, Cologne, Germany.
Birgitta MewesExperimental Medicine, University Hospital of Cologne, Cologne, Germany.
Johannes LindemeyerCore Facility Experimental and Preclinical Imaging Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.
Holger GrüllCore Facility Experimental and Preclinical Imaging Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany.
Albert BuschDivision of Vascular and Endovascular Surgery, Technical University of Dresden and University Hospital Carl-Gustav Carus, Dresden, Germany.
Sebastian ZimmerHeart Center Bonn, Clinic for Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Holger WinkelsHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Hubert SchelzigDepartment of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Malte KelmDepartment of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Georg NickenigHeart Center Bonn, Clinic for Internal Medicine II, University Hospital Bonn, Bonn, Germany.
Stephan BaldusHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Markus U WagenhäuserDepartment of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Martin MollenhauerHeart Center, Department of Cardiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. martin.mollenhauer@uk-koeln.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) remains a significant public health challenge, primarily due to its high mortality rate and the lack of effective preventive and causal strategies. This study aims to establish an improved translational triple-hit porcine model of AAA and to compare it with human AAA disease. AAA was induced in four juvenile domestic pigs by balloon catheter-based aortic dilation, enzyme-mediated extracellular matrix (ECM) degradation, and lysyl oxidase inhibition. The porcine AAA model was characterized by proteomics, histological investigation, and cytokine profiling, and compared with natural occurred human AAA disease. Infrarenal AAA was successfully established with sustained aortic dilation (> 150% of baseline diameter) occurring within 7-14 days post induction and maintained through day 28. Proteomic analysis of porcine AAA tissue identified significant shifts in protein abundance, including downregulation of proteins associated with vascular smooth muscle cell function and ECM integrity, and upregulation of immune-related proteins. Comparative analysis of porcine and human aortic tissues revealed reduced medial elastic fiber content and length, along with increased calcification in porcine AAA, reflecting structural and pathological changes observed in human AAA. Systemic cytokine profiling revealed significant increases in both pro-inflammatory and anti-inflammatory cytokines following AAA induction in pigs, with a cytokine profile largely comparable to that observed in human AAA patients. These findings suggest that the refined porcine AAA model offers a reliable and reproducible platform for investigating AAA progression and evaluating potential therapeutic interventions prior to clinical implementation.

Indexed as

Aortic Aneurysm, AbdominalDisease Models, AnimalAnimalsAorta, AbdominalCytokinesExtracellular MatrixFemaleHumansMaleProteomicsSwineCytokinesAbdominal aortic aneurysm (AAA)Cytokine profilesStructural remodelingSurgical porcine model

Identifiers

PMID41408131
PMCPMC12714784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.