ArticleNPJ Parkinson's disease2025
Cortical dynamics and network alterations in Parkinson's disease with mild cognitive impairment: TMS-EEG study of the posterior parietal cortex.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Eight-year longitudinal changes in functional connectivity of the fatigue network in Parkinson's disease: evidence from four timepoints.Brain imaging and behavior · 2026Article
- Time-Varying Effective Network of Rehabilitation in Parkinson's Disease With Disease Laterality: A TMS-EEG Study.CNS neuroscience & therapeutics · 2026Article
- Dynamic Global and Local Enhancement of Theta-Band Functional Networks as Neural Markers of Spinal Cord Stimulation Efficacy in Disorders of Consciousness.CNS neuroscience & therapeutics · 2026Article
- Multimodal Electrophysiological Signals for Machine Learning-Aided Parkinson's Disease Diagnosis.Biosensors · 2026Article
- Efficacy of rTMS and TBS on the motor symptoms in Parkinson's disease: a network meta-analysis.Journal of neurology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Individuals with mild cognitive impairment (MCI) in Parkinson's disease (PD) are significantly susceptible to developing dementia. Investigating cortical dynamics within the posterior parietal cortex (PPC) may elucidate the mechanisms underlying cognitive decline in PD. Using combined transcranial magnetic stimulation-electroencephalography, this study assessed cortical excitability, time-frequency oscillations, and functional network dynamics after stimulation of the right PPC in 45 PD patients (23 with MCI, 22 with normal cognition). Results showed that PD-MCI patients exhibited increased TMS-evoked potentials across the frontal-parietal-occipital cortex compared to cognitively normal PD patients, accompanied by enhanced theta and alpha oscillation synchronization. Functional connectivity analysis revealed higher global efficiency and lower average shortest path length within theta-band frontoparietal networks in PD-MCI, which correlated with poorer cognitive performance. These results highlight hyperactive cortical responses and hyperconnected low-frequency brain networks in PD-MCI following right PPC stimulation, implicating the PPC as a potential intervention target to mitigate cognitive decline in PD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.