Evidence map›Paper›PMID 41408034›Full record

Trial reportGeroScience2026

Beyond strength: dietary nitrate augments self-selected functional mobility after resistance training in middle-aged adults.

Brandon M Peoples, Mason C McIntosh, Kenneth D Harrison, Bria R Smith, Keven G Santamaria Guzman, Silvia E Campos-Vargas, Damaris C Cifuentes, Breanna J Mueller, Andreas N Kavazis, Darren T Beck and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brandon M PeoplesSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Mason C McIntoshSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Kenneth D HarrisonSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Bria R SmithSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Keven G Santamaria GuzmanSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Silvia E Campos-VargasSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Damaris C CifuentesSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Breanna J MuellerSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Andreas N KavazisSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Darren T BeckSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Michael D RobertsSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA.
Jaimie A RoperSchool of Kinesiology, Auburn University, 301 Wire Road, Office, Auburn, AL, 36849, USA. jroper@auburn.edu.ORCID http://orcid.org/0000-0002-8760-8881

Funding

Edward Via College of Osteopathic Medicine VCOM REAP
6 · The paper itself

Abstract

This study aimed to assess whether dietary nitrate supplementation with resistance training (RT) augments gait performance and functional mobility in inactive middle-aged and older adults. We hypothesized that combining nitrate-rich beetroot juice (BRJ) with RT would yield improvements in gait and functional mobility compared to RT with nitrate-depleted beetroot juice placebo (PLA) supplementation. In this 12-week, randomized, double-blind, placebo-controlled pilot trial, 28 healthy, inactive adults (56 ± 7 years) were assigned to either a BRJ (~ 12.8 mmol nitrate/day) or PLA group while completing a supervised, full-body RT program (2×/week). Pre- and post-intervention assessments included the instrumented stand and walk (iSAW), 6-min walk test (i6MWT), and timed up and go (iTUG) tests. Supplement adherence, training compliance, and volume were equivalent between groups. ANCOVA analyses controlling baseline values revealed significant between-group differences favoring the BRJ group for gait speed (adjusted means: 1.38 vs 1.27 m/s, p = .010), stride length (p < .001), and iTUG duration (p < .05). Within-group analyses confirmed that the BRJ group experienced significant improvements in gait speed (p < 0.001) and iTUG duration (p < 0.05), while the PLA group showed no functional changes, indicating that 12 weeks of RT alone was insufficient to improve functional mobility in our sample despite equivalent training responses (p > .05). In our middle-aged sample, supplementing dietary nitrate alongside RT led to clinically meaningful improvements in functional mobility during self-selected conditions, exceeding the gains from 12 weeks of twice-weekly RT alone. Preliminary descriptive analyses revealed sex-specific group-level differences that might suggest emerging trends. Although no inferential statistics were conducted, the patterns provide potential directions for future research investigating the effects of RT in middle-aged adults.

Indexed as

Dietary SupplementsGaitNitratesResistance TrainingBeta vulgarisDouble-Blind MethodFemaleFruit and Vegetable JuicesHumansMaleMiddle AgedPilot ProjectsNitratesAgingBeetroot juiceDietary nitratesFunctional mobilityGait

Identifiers

PMID41408034
PMCPMC13601425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.