ArticleInflammation2025
L-Carnitine Attenuates Testicular Dysfunction in Type 1 Diabetes Mellitus Via Modulation of Oxidative Stress, Inflammation, and miRNA Expression.
Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Honeybee venom modulates antioxidant gene expression and tissue regeneration in a rat model of staphylococcus aureus - infected skin wounds.Molecular biology reports · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes mellitus (T1DM) is a significant global health concern, adversely affecting various metabolic pathways and organ systems, including male reproductive health. This study aimed to investigate the protective effects of L-carnitine on T1DM-induced testicular dysfunction through its antioxidant and anti-inflammatory mechanisms. Male rats were divided into control, T1DM, L-carnitine, and T1DM + L-carnitine groups. After 8 weeks of treatment, serum glucose, blood HbA1c, testicular oxidative stress markers (TAC, TOS, MDA, and protein peroxidation), Pro-Inflammatory cytokines (IL-1β, IL-6, and TNF-α) and testosterone levels were measured. Additionally, the histological changes, sperm count, and miRNA expression (miR-155, miR-155-5p, and miR-132) were also studied. Results showed that T1DM significantly elevated oxidative stress markers, pro-inflammatory cytokines, and miRNA expression while reducing TAC, testosterone, sperm count, and Johnson’s score. Severe histological alterations, including germinal cell dissociation and atrophied seminiferous tubules, were observed in T1DM rats. L-carnitine treatment reduced oxidative stress and pro-inflammatory cytokines level, decreased lipid and protein peroxidation (> 3-fold), downregulated the miR-155, miR-155-5p, and miR-132 expression in diabetic rats (> 3-fold). Moreover, TAC (> 3-fold), testosterone levels (1-fold), sperm count, and testicular histological changes were restored by L-carnitine in diabetic rats. These findings suggest that L-carnitine ameliorates T1DM-induced testicular dysfunction through its dual antioxidant and anti-inflammatory properties. In line, L-carnitine significantly restored antioxidant capacity by directly scavenging reactive oxygen species, thereby reducing oxidative damage to lipids and proteins. These findings suggest that L-carnitine ameliorates T1DM-induced testicular dysfunction by enhancing antioxidant capacity and downregulating pro-inflammatory miRNAs (miR-155, miR-155-5p, miR-132).
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Registered trials
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