Evidence map›Paper›PMID 41407936›Full record

ArticleLab animal2026

Characterization of a bronchoscopically induced transgenic lung cancer pig model for human translatability.

Kirtan Joshi, Kanve N Suvilesh, Nagabhishek Sirpu Natesh, Yariswamy Manjunath, Jared Coberly, Sarah Schlink, Jeffrey R Kunin, Randall S Prather, Kristin Whitworth, Benjamin Nelson and 8 more

Abstract read
In one paragraph

Article in Lab animal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Kirtan Joshi *Department of Medicine/Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA.
Kanve N Suvilesh *Department of Surgery /Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA.
Nagabhishek Sirpu NateshRoy Blunt NextGen Precision Health Institute, University of Missouri, Columbia, MO, USA.
Yariswamy ManjunathDepartment of Surgery /Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA.
Jared CoberlyDepartment of Clinical Pathology, University of Missouri, Columbia, MO, USA.
Sarah SchlinkOffice of Animal Resources, University of Missouri, Columbia, MO, USA.
Jeffrey R KuninDepartment Of Radiology, University of Missouri, Columbia, MO, USA.
Randall S PratherAnimal Science Research Center of the National Swine Resource and Research Center, University of Missouri, Columbia, MO, USA.ORCID 0000-0002-6012-4035
Kristin WhitworthAnimal Science Research Center of the National Swine Resource and Research Center, University of Missouri, Columbia, MO, USA.
Benjamin NelsonAnimal Science Research Center of the National Swine Resource and Research Center, University of Missouri, Columbia, MO, USA.
Jeffrey N BryanDepartment of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, USA.
Timothy HoffmanDepartment of Medicine/Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA.
Mojgan GolzyBiomedical Informatics, Biostatistics and Medical Epidemiology, University of Missouri, Columbia, MO, USA.
Murugesan RajuInstitute for Data Science and Informatics, University of Missouri, Columbia, MO, USA.
Emma TeixeiroDepartment of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, USA.
Bhanu P TeluguAnimal Science Research Center of the National Swine Resource and Research Center, University of Missouri, Columbia, MO, USA.
Jussuf T KaifiDepartment of Surgery /Ellis Fischel Cancer Center, University of Missouri, Columbia, MO, USA. kaifij@health.missouri.edu.ORCID 0000-0003-3425-2356
Satyanarayana RachaganiRoy Blunt NextGen Precision Health Institute, University of Missouri, Columbia, MO, USA. srachagani@missouri.edu.ORCID 0000-0003-3949-8566

Funding

Resource Core for National Swine Resource and Research Center (NSRRC) Years 21-25U42OD011140 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kiho Lee, Kevin Dale Wells · 2012 to 2026
$26.7M
Swine Somatic Cell Gene Editing Testing Center (Targeted Challenge Testing Center Independent Validation)U42OD035738 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI JONATHAN A GREEN · 2023 to 2026
$7.7M
Targeting tumor and its microenvironment using nanotherapeutics for pancreatic cancerR01CA247763 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RACHAGANI, SATYANARAYANA · 2020 to 2024
$1.9M
CSRD VA I01 CX002498NCI NIH HHS R01 CA247763NIH HHS U42 OD011140NIH HHS U42 OD035738U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1R01CA247763-01A1U.S. Department of Veterans Affairs (Department of Veterans Affairs) CX002498-01A2
6 · The paper itself

Abstract

There remains a need for animal models with human translatability in lung cancer (LC) research. Findings in pigs can have a substantial impact owing to their similar anatomy and physiology to humans. Here we present a bronchoscopically induced LC model in Oncopigs carrying inducible KRAS

Indexed as

BronchoscopyDisease Models, AnimalLung NeoplasmsAnimalsAnimals, Genetically ModifiedFemaleHumansProto-Oncogene Proteins p21(ras)SwineProto-Oncogene Proteins p21(ras)

Identifiers

PMID41407936
PMCPMC12738287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.