Evidence map›Paper›PMID 41407909›Full record

ArticleCommunications biology2025

Cross-species validation of a human age-related hearing loss candidate KLHDC7B as essential for mammalian hearing.

Alexandra M Kaufman, Benjamin Silver, Roberto A Donnianni, Carlos Aguilar, Lingzi Niu, Daniel Johnson, Anwen Bullen, Alma Corona, Benjamin J van Soldt, Nilay Vora and 16 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Alexandra M Kaufman *Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Benjamin Silver *UCL Ear Institute, University College London, London, UK.
Roberto A DonnianniRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Carlos AguilarUCL Ear Institute, University College London, London, UK.ORCID http://orcid.org/0000-0002-4655-1778
Lingzi NiuUCL Ear Institute, University College London, London, UK.
Daniel JohnsonRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Anwen BullenUCL Ear Institute, University College London, London, UK.ORCID http://orcid.org/0000-0002-6705-5263
Alma CoronaRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Benjamin J van SoldtRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Nilay VoraRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-2265-5580
Gervasio BatistaRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Luz Cortes-BurgosRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Jacqueline CopelandRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Elika FallahRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Norman ZhangRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Marina LehmkuhlRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Sarah CancelarichRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Kara CamposRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Daniela Di Battista MianiRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Jaylen MumphreyRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Susan D CrollRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Johnathon R WallsRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Mary GerminoRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Michael R BowlUCL Ear Institute, University College London, London, UK.ORCID http://orcid.org/0000-0001-7971-445X
Meghan C DrummondRegeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Sally J DawsonUCL Ear Institute, University College London, London, UK. sally.dawson@ucl.ac.uk.ORCID http://orcid.org/0000-0002-4421-2043

Funding

Action on Hearing Loss F98Dunhill Medical Trust (DMT) RPGF2002\189 and CER\91RCUK | Medical Research Council (MRC) MC_UP_1503/2 and MR/X004597/1Royal College of Surgeons of England (RCS) Duveen Fellowship in Otology
6 · The paper itself

Abstract

Although age-related hearing loss (ARHL) is the most common sensory loss in older adults, underlying mechanisms remain unclear. Recent genome-wide association studies (GWAS) linked variation in several genes with ARHL risk, including KLHDC7B, a gene of unknown function not previously linked to hearing. We demonstrate Klhdc7b is expressed exclusively in sensory hair cells in mouse cochlea. Utilizing two independent mouse knockout models (Klhdc7b

Indexed as

AgingHearingPresbycusisAnimalsCochleaDisease Models, AnimalFemaleGenome-Wide Association StudyHair Cells, AuditoryHumansMaleMiceMice, Inbred C57BLMice, KnockoutSpecies Specificity

Identifiers

PMID41407909
PMCPMC12820229

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.