ArticleNature2026
Lesion-remote astrocytes govern microglia-mediated white matter repair.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Lipid droplets as redox-active organelles after spinal cord injury: lipid peroxidation, mitochondrial dysfunction, and neuroinflammation.Redox report : communications in free radical research · 2026Review
- Review
- Broad-Coverage Lipidomics Reveals Temporal Lipid Remodeling and Candidate Serum Biomarkers After Acute Spinal Cord Injury in Rats.Biomedicines · 2026Article
- TRIM28 SUMOylates IRF3 in astrocytes to drive neutrophils infiltration and ischemic cerebral injury.Cell death and differentiation · 2026Article
- Microglia and neuroinflammation: function, heterogeneity, and crosstalk.Cellular & molecular immunology · 2026Review
- Article
- Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network Collapse.International journal of molecular sciences · 2026Review
- Microglial lipid metabolism and epigenetic regulation: Emerging targets for spinal cord injury therapy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Regional Molecular Diversity in Chronic Spinal Cord Injury.Cellular and molecular neurobiology · 2026Article
- Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation.Neurology international · 2026Review
- Emerging strategies for spinal cord injury repair: stem cells, extracellular vesicles, biomaterials, and neuromodulation.Frontiers in bioengineering and biotechnology · 2026Review
- Mechanical Remodeling and Mechanosensing after Spinal Cord Injury: From Molecular to Translational Approaches.Research (Washington, D.C.) · 2026Review
- Multi-omics analysis identifies NFIL3 as a hypoxia-associated immune regulator in septic cardiomyopathy.Frontiers in immunology · 2026Article
- Mechanisms underpinning spontaneous spinal cord regeneration.Development (Cambridge, England) · 2025Review
- Article
- Review
- Review
- Review
- An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Update of
Authors and funding
23 authors.
Sarah McCallum *Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-2156-3219
Keshav B Suresh *Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Timothy S IslamDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0008-7903-9448
Manish K TripathiDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ann W SaustadDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0000-0271-8946
Oksana ShelestBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aditya PatilDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
David LeeDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Brandon KwonDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Katherine LeitholfDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Inga YenokianDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sophia E ShakaDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-4441-9773
Connor H BeveridgeDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Palak ManchandraDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Caitlin E RandolphDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Gordon P MearesDepartment of Neurology, The Neuroscience Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Ranjan DuttaDepartment of Neuroscience, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-8502-4455
Jasmine PlummerDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0001-7263-350X
Vinicius F CalsavaraDepartment of Computational Biomedicine Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-2332-5863
Riki KawaguchiProgram in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2489-4825
Simon R V KnottDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-4018-7653
Gaurav ChopraDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-0942-7898
Joshua E BurdaDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. joshua.burda@csmc.edu.ORCID 0000-0001-5139-348X
Funding
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4MPathogenesis of Neurological Disability in Primary Diseases of MyelinR35NS097303 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI TRAPP, BRUCE D · 2017 to 2024
$6.9MPERK Dependent Mechanisms of NeuroinflammationR01NS099304 · NINDS · WEST VIRGINIA UNIVERSITY · PI Gordon P. Meares · 2017 to 2026
$4.1MInterrogating a white matter degeneration-specific astrocyte reactivity state and its role in governing repair-associated microglia specification and function.R01NS128094 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI Joshua Evan Burda · 2023 to 2026
$2.7MUnderstanding role of circadian disruption in pathogenesis of MSR01NS123532 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Ranjan Dutta, sujata Rao · 2022 to 2026
$2.2MDevelopment of a high throughput system for molecular imaging of different cell types in mouse brain tissuesRF1MH128866 · NIMH · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, LASKIN, JULIA · 2021 to 2021
$1.5MChemical instruments-aware distributed blockchain based open AI platform to accelerate drug discoveryU18TR004146 · NCATS · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, JAYACHANDRAN, GUHA · 2022 to 2023
$1.1MAstrocyte Regulation of Neural Plasticity After CNS InjuryR00NS105915 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI BURDA, JOSHUA EVAN · 2019 to 2021
$739kEstablishing reactive astrocyte memory as a risk factor for aging-related neurodegenerative diseaseK99AG084864 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MCCALLUM, SARAH · 2024 to 2025
$216kAstrocyte regulation of neural plasticity after CNS injuryK99NS105915 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURDA, JOSHUA EVAN · 2018 to 2019
$186kInterrogating the Potential of Ccn1+ Astrocyte Niches to Drive Angiogenesis after Spinal Cord InjuryF31NS129372 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI SURESH, KESHAV BALAJI · 2023 to 2024
$83kNCATS NIH HHS U18 TR004146NCI NIH HHS P30 CA023168NIA NIH HHS K99 AG084864NIMH NIH HHS RF1 MH128866NINDS NIH HHS F31 NS129372NINDS NIH HHS K99 NS105915NINDS NIH HHS R00 NS105915NINDS NIH HHS R01 NS099304NINDS NIH HHS R01 NS123532NINDS NIH HHS R01 NS128094NINDS NIH HHS R35 NS097303
Abstract
Spared regions of the damaged central nervous system undergo dynamic remodelling and exhibit a remarkable potential for therapeutic exploitation
Indexed as
AstrocytesMicrogliaSpinal Cord InjuriesWhite MatterAnimalsAxonsCysteine-Rich Protein 61FemaleHumansLipid DropletsLipid MetabolismMaleMiceMice, Inbred C57BLMyelin SheathCCN1 protein, mouseCysteine-Rich Protein 61
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.