Evidence map›Paper›PMID 41407801›Full record

ArticleScientific reports2025

The effects of graded hypoxia on gene expression related to oxygen sensing and metabolism.

Josey Walker, Brent Ruby, Dustin Slivka

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Josey WalkerSchool of Integrative Physiology and Athletic Training, College of Health, University of Montana, Missoula, MT, USA.
Brent RubySchool of Integrative Physiology and Athletic Training, College of Health, University of Montana, Missoula, MT, USA.
Dustin SlivkaSchool of Integrative Physiology and Athletic Training, College of Health, University of Montana, Missoula, MT, USA. Dustin.Slivka@mso.umt.edu.

Funding

U.S. Army Medical Department USAMR&MC #W81XWH-10-2-0120
6 · The paper itself

Abstract

To improve performance at altitude some endurance athletes undergo exposure to hypoxic stimulus during post exercise recovery, but this may impact gene expression related to exercise adaptation. The purpose of this study is to determine a hypoxic threshold and its impact on gene expression related to oxygen sensing, metabolism, and mitochondrial dynamics. Ten male participants (24 ± 4 years, 47.1 ± 9.5 ml·kg

Indexed as

Gene Expression RegulationHypoxiaOxygenAdultAltitudeExerciseHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMuscle, SkeletalOxygen ConsumptionPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaYoung AdultHypoxia-Inducible Factor 1, alpha SubunitOxygenPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaHIF-1αNormobaricPGC-1αRecoverySimulated altitude

Identifiers

PMID41407801
PMCPMC12804853

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.