Evidence map›Paper›PMID 41407760›Full record

ArticleScientific reports2025

Rumen metabolic environment of dairy cows varying in susceptibility of subacute ruminal acidosis modifies in vitro bacterial composition and fermentation.

H Yang, S Heirbaut, J Jeyanathan, X P Jing, M Q Zhang, N De Neve, L Vandaele, V Fievez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

H YangSchool of Animal Science and Technology, Jiangsu Agri-animal Husbandry Vocational College, Taizhou, China.
S HeirbautDepartment of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Campus Coupure, Building F, 1 st Floor, Coupure Links 653, Ghent, 9000, Belgium.
J JeyanathanDepartment of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Campus Coupure, Building F, 1 st Floor, Coupure Links 653, Ghent, 9000, Belgium.
X P JingDepartment of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Campus Coupure, Building F, 1 st Floor, Coupure Links 653, Ghent, 9000, Belgium.
M Q ZhangDepartment of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Campus Coupure, Building F, 1 st Floor, Coupure Links 653, Ghent, 9000, Belgium.
N De NeveDepartment of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Campus Coupure, Building F, 1 st Floor, Coupure Links 653, Ghent, 9000, Belgium.
L VandaeleFisheries and Food, Animal Sciences Unit, Flanders Research Institute for Agriculture, Scheldeweg 68, Melle, 9090, Belgium.
V FievezDepartment of Animal Sciences and Aquatic Ecology, Faculty of Bioscience Engineering, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Campus Coupure, Building F, 1 st Floor, Coupure Links 653, Ghent, 9000, Belgium. Veerle.Fievez@UGent.be.

Funding

Flanders Innovation & Entrepreneurship LA170830innovation program under grant agreement 101000213-HoloRuminant 101000213-HoloRuminantJiangsu Province Natural Science Foundation for Youths BK20240528Natural Science Foundation of Jiangsu Agri-animal Husbandry Vocational College NSF2024CB02University natural science research project in Jiangsu Province 23KJD230002
6 · The paper itself

Abstract

The rumen metabolic environment from either SARA susceptible (S) or unsusceptible (U) cows, was hypothesized to alter the fermentative capacity and bacterial community composition. This was evaluated in vitro through exposure for a period of 24 h of the microbial inoculum of three donor cows to sterile ruminal supernatant obtained from a subset of 15 out of a group of 38 early lactating dairy cows which were either SARA S (n = 8) or U (n = 7) cows at pH 5.8 and 6.8. Compared to exposure to sterile supernatant from S cows, microbiota exposed to sterile supernatant from U cows produced more total volatile fatty acids, irrespective of the in vitro pH (6.8 or 5.8). Specifically, branched-chain volatile fatty acids (BCVFA), such as isobutyrate and total BCVFA are elevated/tended to be elevated in incubations with the sterile supernatant from U cows. Net lactate accumulation in incubations with U cows' supernatant at pH 6.8 was higher than with S cows' supernatant. Nevertheless, a lower relative abundance of Firmicutes, uncultured Ruminococcaceae, Lachnospiraceae_UCG-008, and Anaerovoracaceae Mogibacterium, as well as a higher relative abundance of Prevotella was observed after incubation with sterile supernatant from SARA S cows as compared with SARA U cows.

Indexed as

AcidosisBacteriaCattle DiseasesFermentationRumenAnimalsCattleDisease SusceptibilityFatty Acids, VolatileFemaleGastrointestinal MicrobiomeHydrogen-Ion ConcentrationFatty Acids, VolatileInter-animal variationIn vitro simulationMicrobial metabolitesRumen microbiotaSubacute ruminal acidosis

Identifiers

PMID41407760
PMCPMC12775452

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.