Evidence map›Paper›PMID 41407757›Full record

ArticleScientific reports2025

Quantitative lung particulate analysis links increased anthracotic pigment burden to burn pit exposure in post-9/11 veterans with distal lung disease.

Jeremy T Hua, Lauren M Zell-Baran, Carlyne D Cool, Silpa D Krefft, Leonard H T Go, Robert A Cohen, Susan M Majka, Cecile S Rose

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jeremy T HuaDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO, USA. huaj@njhealth.org.
Lauren M Zell-BaranDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO, USA.
Carlyne D CoolDepartment of Pathology, University of Colorado School of Medicine, Aurora, CO, USA.
Silpa D KrefftDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO, USA.
Leonard H T GoDivision of Environmental and Occupational Health Sciences, University of Illinois Chicago School of Public Health, Chicago, IL, USA.
Robert A CohenDivision of Environmental and Occupational Health Sciences, University of Illinois Chicago School of Public Health, Chicago, IL, USA.
Susan M MajkaDivision of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Cecile S RoseDivision of Environmental and Occupational Health Sciences, National Jewish Health, Denver, CO, USA.

Funding

Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to EmphysemaR35HL161238 · NHLBI · NATIONAL JEWISH HEALTH · PI SUSAN M MAJKA · 2022 to 2026
$4.9M
Loss of progenitor function accelerates lung agingR01AG073317 · NIA · NATIONAL JEWISH HEALTH · PI SUSAN M MAJKA, Richard Lee Reinhardt · 2023 to 2026
$2.7M
NHLBI NIH HHS R35 HL161238NIA NIH HHS R01 AG073317State of Colorado Advanced Industries Proof-of Concept Grant CTGG1 2023-3436
6 · The paper itself

Abstract

Military deployment to Southwest Asia and Afghanistan is linked to complex hazardous airborne exposures, but ascertaining the contributions of specific environmental toxicants in causing or contributing to deployment-related distal lung diseases (DDLD) remains challenging. We applied a quantitative microscopy for particulate matter (QM-PM) technique to measure the in situ burden of pigmented and birefringent lung particulates in 24 veterans with DDLD, 10 smokers with respiratory bronchiolitis (RB), and 10 healthy controls. Veterans were more likely to be male (88%) and were significantly younger than RB and healthy controls (mean age 41 vs. 47 vs. 53 years, respectively). Adjusting for age, the anthracotic pigment fraction in lung tissue from DDLD was similar to RB (1.69% vs. 1.37%, P = 0.72), and was significantly greater than healthy controls (0.52%, P = 0.02). Pigment fraction in veterans was significantly associated with higher reported burn pit smoke exposure (P = 0.02), but not sandstorms or diesel exhaust. Birefringent dust density, indicating retained silica/silicates, was significantly increased in RB (28.89/mm

Indexed as

AnthracosisBronchiolitisMilitary DeploymentOpen Waste BurningParticulate MatterAdolescentAdultAgedAsia, WesternBiopsyCase-Control StudiesFemaleHumansInhalation ExposureLungMaleParticulate MatterSmokeBronchiolitisCoal miningLung histologyMilitary deploymentOccupational dustTobacco smoking

Identifiers

PMID41407757
PMCPMC12712081

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.