ArticleNature communications2025
Alternative antigen retention by a gp96-fusion approach induces long-lasting and broad immunity in mice.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Increasing hydrophobicity in poly(amino acid) adjuvants elicits potent and durable anti-tumor immunityBioactive materials · 2027Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Efficient antigen delivery to B cells and dendritic cells (DC) is critical for enhancing vaccine immunogenicity. Here, we develop a dimeric vaccine strategy by fusing antigens to the N-terminal of heat shock protein GP96. This platform generates compact, nanoscale particles that fully exposed antigenic sites. We validate the vaccine strategy using the SARS-CoV-2 receptor-binding domain (RBD) antigen in a viral challenge model with hACE2 mice and the human papillomavirus (HPV) E7 protein in a HeLa xenograft model with nude mice. The GP96 moiety directly bound its receptor, LRP1, thereby enhancing antigen accumulation on follicular DCs and prolonging lymph node retention, ultimately amplifying germinal center B cell responses. Furthermore, GP96-LRP1 interaction on DCs promotes antigen endocytosis, underpinning epitope presentation and robust cross-conserved T cell activation. Consequently, this design induces potent, durable humoral immunity, cross-conserved T cell responses, and pulmonary mucosal immunity, underscoring its promise as a versatile and effective vaccination strategy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.