Evidence map›Paper›PMID 41407681›Full record

ArticleNature communications2025

Biomimetic transmembrane transport of multi-enzymes to fabricate heterogeneous bioreactors with photoenzymatic reduction of CO

Qianqian Zhu, Yunlong Zheng, Jiangyue Yu, Jin Li, Heng Hu, Zhifang Wang, Qiongyu Shi, Zhenjie Zhang, Yao Chen

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qianqian ZhuState Key Laboratory of Biopharmaceutical Preparation and Delivery, Chinese Academy of Sciences, Beijing, China.
Yunlong ZhengState Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin, China.
Jiangyue YuState Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin, China.
Jin LiState Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin, China.
Heng HuState Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin, China.
Zhifang WangDepartment of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, Tianjin, China.
Qiongyu ShiState Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin, China.
Zhenjie ZhangState Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, Tianjin, China.ORCID http://orcid.org/0000-0003-2053-3771
Yao ChenState Key Laboratory of Biopharmaceutical Preparation and Delivery, Chinese Academy of Sciences, Beijing, China. chenyao@nankai.edu.cn.ORCID http://orcid.org/0000-0002-3465-7380

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cascade of bio-/chemo-catalysis with quantitative integration and optimal activity is vital for catalytic conversion, but highly challenging. Here, we innovate a co-immobilization strategy by mimicking cellular transmembrane transport using ionic covalent organic framework capsules (iCOFcap) to co-encapsulate multi-enzymes and chemocatalysts. Thanks to the swellable polyethylene glycol and the adjustable charge of iCOFcap shells, multi-enzymes can be adsorbed onto the iCOFcap shells and then transported stepwise into the inner cavity of iCOFcap by adjusting electrostatic interaction between the enzymes and iCOFcap. Thus, the iCOFcap enables both transmembrane transport multi-enzymes and one-pot pre-encapsulation of chemocatalysts to construct various cascade catalysts, enabling quantitative integration and nearly complete retention of enzyme activity. The formed heterogeneous cascade catalysts show excellent comprehensive performance for CO

Indexed as

BiomimeticsBioreactorsCarbon DioxideBiocatalysisCatalysisEnzymes, ImmobilizedMetal-Organic FrameworksOxidation-ReductionPolyethylene GlycolsCarbon DioxideEnzymes, ImmobilizedMetal-Organic FrameworksPolyethylene Glycols

Identifiers

PMID41407681
PMCPMC12717274

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.