ArticleNature communications2025
The gut vagal sensory pathway drives postprandial sleep via activation of PVH-projecting GABAergic neurons in the NTS.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The lung-gut-brain axis in non-small-cell lung cancer: a narrative review with a systematic search of three signaling pathways.Frontiers in immunology · 2026Pooled it
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Authors and funding
9 authors.
Funding
Abstract
Feeding status bidirectionally modulates sleep; however, the neural circuitry that integrates the sensing of gastrointestinal (GI) state and sleep remains poorly understood. The afferent fibers of the vagus nerve extensively innervate the GI tract, transmitting postprandial satiety signals to the brain. This study investigates the key role of the upper gut-innervating vagal sensory neurons in modulating sleep-wake states and promoting postprandial sleep, uncovering the underlying circuit mechanisms. Both feeding and activation of stomach/duodenum-innervating vagal sensory neurons reduce wakefulness and increase NREM sleep in male mice. Conversely, chemogenetic inhibition abolished the sleep-promoting effects of feeding. Using anterograde transsynaptic tracing, single-nucleus RNA sequencing combined with optogenetic manipulation, we identified a vagal ascending pathway connecting the upper gut to the paraventricular nucleus of the hypothalamus (PVH) via GABAergic neurons in the nucleus of solitary tract (NTS). Stomach/duodenum-innervating vagal sensory neurons project directly to and functionally activate NTS GABAergic neurons. Activation of these neurons and their projections to the PVH suppressed wakefulness and prolonged NREM sleep. Overall, our study reveals a vagal sensory pathway that integrates satiety signals to modulate sleep. It reveals the direct neural circuitry mechanisms driving postprandial sleep and offers distinctive perspectives into the development of innovative interventions for sleep disorders.
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