Evidence map›Paper›PMID 41407569›Full record

ArticleBrachytherapy

Low dose iodine-125 brachytherapy and transpupillary thermal therapy for small- to medium-sized choroidal melanoma.

S Fattahi, C L Deufel, K V Astafurov, T W Olsen, S L Stafford, M A Neben Wittich, W S Harmsen, J K Viehman, L A Dalvin, I A Petersen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brachytherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

S FattahiHarvard Radiation Oncology Program, Boston, MA.
C L DeufelMayo Clinic Department of Radiation Oncology, Rochester, MN.
K V AstafurovMonmouth Retina Eyecare Partners, Manalapan, NJ.
T W OlsenEmory University School of Medicine Department of Ophthalmology, Atlanta, GA.
S L StaffordMayo Clinic Department of Radiation Oncology, Rochester, MN.
M A Neben WittichMayo Clinic Department of Radiation Oncology, Rochester, MN.
W S HarmsenMayo Clinic Division of Biomedical Statistics and Informatics, Rochester, MN.
J K ViehmanNorth American Science Associates, Northwood, OH.
L A DalvinMayo Clinic Department of Ophthalmology, Rochester, MN.
I A PetersenMayo Clinic Department of Radiation Oncology, Rochester, MN.
K S CorbinMayo Clinic Department of Radiation Oncology, Rochester, MN. Electronic address: Corbin.Kimberly@mayo.edu.

Funding

Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
NCATS NIH HHS KL2 TR002379
6 · The paper itself

Abstract

purposeCOMS established iodine-125 (

methodsPatients diagnosed 2005-2019 with choroidal melanoma <5 mm thick and managed with

results143 patients met inclusion criteria with median follow-up of 7 years. Five-year Kaplan-Meier estimates of ocular AEs were 59.6% radiation maculopathy, 42.0% cystoid macular edema, 55.2% nonproliferative radiation retinopathy, 10.8% proliferative radiation retinopathy, and 35.6% radiation papillopathy. Five-year cumulative incidence of local recurrence was 0%, 5-year cumulative incidence of distant metastasis was 6.1%, and 5-year Kaplan-Meier estimate of overall survival was 96.5%.

conclusionReduced dose

Indexed as

BrachytherapyChoroid NeoplasmsHyperthermia, InducedIodine RadioisotopesMelanomaAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRadiotherapy DosageRetrospective StudiesIodine-125Iodine RadioisotopesChoroidal melanomaCOMS plaquesIodine-125 brachytherapyMonte-Carlo dosimetryOcular adverse eventsOcular melanomaReduced dose brachytherapyTranspupillary thermal therapyTumor control

Identifiers

PMID41407569
PMCPMC13007048

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.