ArticleAnnals of laboratory medicine2026
High-Resolution Eight-Digit Human Leukocyte Antigen-A, -B, -C, and -DRB1 Allele and Haplotype Frequencies in South Koreans Using Next-Generation Sequencing.
Article in Annals of laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Expanding the spectrum of post-HSCT hemolysis: from passenger lymphocyte syndrome to host- and graft-associated alloimmune hemolytic anemia.Blood research · 2026Review
- Length Matters: Toward the Clinical Adoption of Long-Read Sequencing.Annals of laboratory medicine · 2026Article
- Advances in HLA and Non-HLA Immune Profiling: Integrating Next-Generation Sequencing and Artificial Intelligence in Transplantation.Annals of laboratory medicine · 2026Review
- Toward a More Complete High-Resolution Human Leukocyte Antigen Reference for Koreans.Annals of laboratory medicine · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Background: Data on human leukocyte antigen (HLA) typing using modern high-resolution methods are increasingly needed. Previous HLA studies in Korea were limited by small sample sizes or low-resolution data. We analyzed high-resolution (eight-digit) HLA data obtained through next-generation sequencing from healthy volunteers from Korea registered for hematopoietic stem cell transplantation, providing a large-scale dataset for population-based genetic analysis. Methods: We comprehensively analyzed HLA data from 2,726 volunteers from Korea. HLA-A, -B, -C, and -DRB1 alleles were identified using a GenDX NGSgo kit. Allele frequency (AF), haplotype frequency (HF), and equilibrium status were analyzed using the PyPop software. Principal component, Euclidean distance, and Nei's standard genetic distance analyses were performed using R software to compare data from Korea with that from other East Asian populations. Results: AF analysis identified 222 alleles (52 HLA-A, 70 HLA-B, 59 HLA-C, and 41 HLA-DRB1); Conclusions: This study revealed key population genetic trends and relationships with East Asian neighbors, reflecting both shared and distinctive HLA characteristics. These data can provide valuable insights for anthropological and clinicopathological studies, as well as for understanding genetic diversity within the East Asian region.
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