Development of Marine-Lenhart Syndrome during the Course of Acromegaly.

Momo Saito, Yosuke Okada, Fumi Uemura, Yoshiya Tanaka

Abstract readCase Reports

In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Momo SaitoThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Yosuke OkadaThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Fumi UemuraThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Yoshiya TanakaThe First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 76-year-old woman was diagnosed with acromegaly and underwent resection of a transsphenoidal pituitary tumor. Central hypothyroidism was detected before surgery and the patient was treated with levothyroxine. Insulin-like growth factor-1 (IGF-1) levels remained abnormal after surgery. Follow-up showed an increase in free thyroxine levels even after discontinuation of levothyroxine; thereafter, Marine-Lenhart syndrome was diagnosed. The initiation of treatment with a somatostatin analog for acromegaly and thiamazole for Marine-Lenhart syndrome was followed by normalization of IGF-1 levels and thyroid function test results. Coexistent thyrotoxicosis is rare in patients with acromegaly; therefore, attention should be paid to elderly patients, as they exhibit only a few symptoms.

Indexed as

AcromegalyThyrotoxicosisAgedFemaleHumansHypothyroidismInsulin-Like Growth Factor IMethimazolePituitary NeoplasmsSomatostatinSyndromeThyroxineInsulin-Like Growth Factor IMethimazoleSomatostatinThyroxineacromegalygrowth hormoneinsulin-like growth factor-1Marine-Lenhart syndromethyroid-stimulating hormone

Identifiers

PMID41407338

DOI10.2169/internalmedicine.5550-25

PMCPMC13521631

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.