ArticleVox sanguinis2026
Dengue, chikungunya and Zika virus surveillance in blood donors in Brazil, 2019-2021.
Article in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Dengue, chikungunya and Zika virus surveillance in blood donors in Brazil, 2019-2021.Vox sanguinis · 2026Article
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Authors and funding
19 authors.
Funding
Abstract
BACKGROUND AND
objectivesArbovirus infections are a major public health concern in Brazil and an ongoing blood safety concern. Periodic outbreaks of such infections are common in the general population. This study aimed to establish the rates of dengue, chikungunya and Zika virus (DENV, CHIKV, ZIKV) RNAemia among blood donors at six public blood centres during the 2019-2020 and 2020-2021 outbreak seasons. MATERIALS AND
methodsResidual minipool samples from nucleic acid testing (NAT) screening for human immunodeficiency virus, hepatitis B virus and hepatitis C virus were further pooled to form pools of 18 donation samples and tested using a Grifols research-use-only triplex transcription-mediated amplification assay for DENV, CHIKV and ZIKV RNA to establish the rates of RNAemia and infection incidence. We used these rates and estimated the durations of RNAemia, juxtaposed with public health reporting of cases.
resultsA total of 5,616 minipools representing 101,088 donations were tested. During both outbreak seasons, the highest rates of DENV RNAemia were observed in Ribeirão Preto, at 122/100,000 donations (95% confidence interval [CI]: 66-224) and 100/100,000 (95% CI: 52-189), respectively, with DENV RNAemia also detected in São Paulo, Recife and Manaus in the 2019/2020 season and in the latter two during the 2020/2021 season. CHIKV RNAemia was detected in Recife and ZIKV RNAemia in Manaus during the 2020/2021 season. The estimated numbers of DENV, CHIKV and ZIKV RNAemic components released for transfusion over the study period were 338, 22 and 6, respectively.
conclusionSurveillance for arbovirus RNAemia in blood donors is a useful adjunct to public health surveillance, particularly when surveillance systems are under strain, and has implications for transfusion safety.
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