Evidence map›Paper›PMID 41407313›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

GSNOR deletion differentially alters age-related cardiac function in a sex-dependent manner.

Obialunanma V Ebenebe, Raihan Kabir, Allison Booher, Haley Garbus, Charles D Cohen, Vivek Jani, Brian L Lin, Luigi Adamo, Mark J Kohr

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Obialunanma V EbenebeCardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0001-5238-928X
Raihan KabirDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.ORCID 0000-0001-5863-5760
Allison BooherCardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Haley GarbusDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.ORCID 0000-0003-2304-3559
Charles D CohenCardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Vivek JaniCardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-3811-4973
Brian L LinCardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-0800-7103
Luigi AdamoCardiology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Mark J KohrDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States.ORCID 0000-0002-6034-5962

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
S-nitrosation in cell survival and cell deathR01HL136496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2018 to 2022
$2.0M
Role of formaldehyde, formate and one-carbon metabolism in the female heartR21HL157800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2021 to 2022
$450k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01-HL136496HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R21-HL157800HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32-HL007227NHLBI NIH HHS R01 HL136496NHLBI NIH HHS R21 HL157800NHLBI NIH HHS T32 HL007227
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgingAldehyde OxidoreductasesMyocardial ContractionMyocytes, CardiacVentricular Function, LeftAge FactorsAlcohol DehydrogenaseAnimalsCalcium SignalingFemaleMaleMiceMice, Inbred C57BLMice, KnockoutSarcomeresSex FactorsAdh5 protein, mouseAlcohol DehydrogenaseAldehyde Oxidoreductasesformaldehyde dehydrogenase, glutathione-independentagingcardiomyocyte functionproteomicssex differencesS-nitrosoglutathione reductase

Identifiers

PMID41407313
PMCPMC12954546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.