ArticleClinical transplantation and research2026
Autologous bone marrow mononuclear cell administration in a large cohort of 1,011 patients with autism spectrum disorder: a retrospective observational study.
Article in Clinical transplantation and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes.International journal of molecular sciences · 2023Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This retrospective observational study analyzed the therapeutic efficacy of autologous bone marrow mononuclear cells (BMMNCs) in a large cohort of patients with autism spectrum disorder (ASD). Methods: Overall, 1,011 patients with ASD who received intrathecal administration of autologous BMMNCs were included. Changes in symptoms and outcome measures-the Indian Scale of Autism Assessment (ISAA) and Childhood Autism Rating Scale (CARS)-were recorded. Brain positron emission tomography computed tomography (PET/CT) was used to objectively assess changes in brain metabolism. Results: At a mean follow-up of 19.3 months, 90.6% of patients showed improvement after cell therapy. Symptomatic improvements were observed in attention and concentration, command following, eye contact, sitting tolerance, social interaction, hyperactivity, communication, speech, stereotypical behavior, aggressiveness, and self-injurious behavior. Patients who received multiple doses of cell therapy demonstrated better outcomes, and improvements were seen across all age groups and regardless of disease severity. Changes in ISAA and CARS scores were statistically significant (P<0.05). Comparative PET/CT scans of 401 patients revealed improved metabolism in the amygdala, hippocampus, parahippocampal gyrus, caudate nucleus, cerebellum, mesial temporal lobe, thalamus, and superior and middle temporal poles, which corresponded to symptomatic improvements. No major adverse events were reported. Nine of the 1,011 patients experienced seizures, four of whom had a prior history. These events were managed with medication, with improvements still observed in the nine patients. Conclusions: Intrathecal transplantation of autologous BMMNCs, combined with neurorehabilitation, yields positive outcomes for patients with ASD. This approach helps reduce the degree of impairment and improves quality of life.
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