ArticleEuropean heart journal2025
Nicotine and the cardiovascular system: unmasking a global public health threat.
Article in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between electronic cigarette use and prediabetes, diabetes, and insulin resistance: a systematic review and meta-analysis.Internal and emergency medicine · 2026Pooled it
- Tobacco and marijuana induce adverse effects on cardiac function and platelet activity and reduce tissue preservation following myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2026Article
- Association between current heated tobacco product use and incident hypertension: A nationwide real-world cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- "Cannabis Green Wave" versus "Nicotine Freeze": the regulatory paradox of cannabis liberalization and nicotine prohibition.Harm reduction journal · 2026Article
- Beyond Combustion: Oxidative Stress as a Shared Pathway of Harm Across Conventional Cigarettes, Heated Tobacco Products, E-Cigarettes, and Waterpipe Smoking.Antioxidants (Basel, Switzerland) · 2026Article
- Inferior ST-elevation myocardial infarction associated with premature coronary atherosclerosis in a 21-year-old smoker: a case report.European heart journal. Case reports · 2026Article
- Gambling Disorder as a Behaviorally Driven Systemic Medical Condition: From Reward Circuitry to Multi-System Morbidity.Clinics and practice · 2026Review
- Combustible Cigarette Smoking, Electronic Cigarette Use, and Metabolic Syndrome in a Working Population.Epidemiologia (Basel, Switzerland) · 2026Article
- Nicotine-Mediated Redox and Nitrosative Stress in Cardiorenal Health.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Misplaced optimism about e-cigarettes for smoking cessation in New Zealand.The Lancet regional health. Western Pacific · 2026Article
- Vaping-related lung disease: a narrative review.Journal of thoracic disease · 2026Review
- Nicotine as a cardiovascular drug: haemodynamic stress, oxidative injury, and the regulatory failure to protect the heart.European heart journal open · 2026Article
- Unmasking flawed exposure attribution in nicotine and cardiovascular risk.European heart journal open · 2026Article
- Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026Review
- The dual role of APOE ε4 allele in cerebral small vessel disease: independent genetic effects and effect modification of traditional risk factors.Frontiers in neurology · 2026Article
- Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Preferred Sources of Health-Risk Information About Cigarettes, e-Cigarettes, and Waterpipes Among Adolescents in Germany: A Cross-Sectional Analysis of a Large School-Based Survey.Tobacco use insights · 2026Article
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Abstract
Nicotine-containing products, whether combustible or smokeless, pose a growing threat to cardiovascular (CV) health. While tobacco smoking continues to cause millions of deaths annually, the rapid uptake of e-cigarettes, heated tobacco, and synthetic nicotine pouches, particularly among the youth, risks reversing decades of progress in tobacco control. In this policy statement, 12 evidence-based key messages that highlight the CV toxicity of nicotine are presented, irrespective of delivery system, and the urgent need for comprehensive regulations. These messages address the vascular and metabolic harms of nicotine, the dangers of passive exposure, the key pathophysiological pathways leading to CV morbidity and mortality, and the economic burden of nicotine-induced CV disease. Importantly, this is the first expert consensus paper to address nicotine itself as a direct CV toxin, independent of combustion. Special attention is given to the paediatric addiction crisis, driven by flavoured products and aggressive marketing, and to the misleading narrative of 'safer nicotine.' This paper appears at a critical regulatory turning point: the European Commission's revised Tobacco Taxation Directive (July 2025), which for the first time introduces minimum excise duties on e-liquids, heated tobacco, and nicotine pouches. While this directive represents an important step, it must be complemented by broader regulations, including advertising bans, flavour restrictions, and indoor-use prohibitions, applied consistently across all nicotine products. Together, the 12 key messages provide a policy blueprint to protect CV health and prevent the rise of a new generation of nicotine-addicted youth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.