ArticleAmerican journal of human genetics2026
Genetic control of non-coding RNAs in the human brain and their implications for complex traits.
Article in American journal of human genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mapping genetic regulation of gene expression to cellular contexts identifies long non-coding RNAs associated with brain disorders.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-coding RNAs (ncRNAs) play crucial roles in the regulation of gene expression, but their genetic underpinnings and roles in human traits and diseases remain largely elusive. Here, we identified 38,441 long non-coding RNAs (lncRNAs) and 23,548 circular RNAs (circRNAs) from RNA sequencing (RNA-seq) data of 2,865 human cortex samples, of which 27,453 lncRNAs and all circRNAs were not reported in GENCODE. Expression quantitative trait locus (eQTL) analyses identified cis-eQTLs for 15,362 lncRNAs and 1,312 circRNAs. We showed that lncRNA- or circRNA-eQTLs were largely independent of, and had larger effects on average than, eQTLs of their adjacent or parental protein-coding genes (PCGs). The circRNA-eQTLs were highly enriched in canonical splice sites, highlighting the crucial role of back-splicing in circRNA biogenesis. LncRNA-eQTLs were enriched for heritability of brain-related complex traits and associated with 72 (11.2%) of the colocalized genome-wide association study (GWAS) signals that showed no evidence of colocalization with PCG-eQTLs or splicing quantitative trait loci (QTLs) identified in the same dataset. We showcased lncRNAs (e.g., those near VPS45, MAPT, and RGS6) and circRNAs (e.g., that for GRIN2A) that may be implicated in complex traits through genetic regulation of ncRNAs. Our study provides insights into the genetic regulation of ncRNAs and their implications in brain-related complex traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.