ArticleCell2025
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses.
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Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Efficacy and immunological correlates of an mRNA-LNP vaccine for protection against an emerging rickettsial pathogen.Emerging microbes & infections · 2026Article
- Spatiotemporal heterologous vaccination relies on type I interferons at priming to enhance mucosal immunity.EMBO molecular medicine · 2026Article
- Bioengineering strategies for improving the immunogenicity of mRNA vaccines.Signal transduction and targeted therapy · 2026Review
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Spatiotemporal control of STING activation and saRNA delivery decouples humoral and cellular immunity.bioRxiv : the preprint server for biology · 2026Article
- Multifunctional Nanovaccine-Radiotherapy Synergy Drives Anti-Tumor Immunity via Multi-Cascade Cell Death for Pancreatic Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Enhanced Humoral and Cellular Immune Responses Elicited by a Liposomal Subunit Vaccine Based onVeterinary sciences · 2026Article
- mRNA-based influenza vaccine expands the B cell response breadth in humans.Nature immunology · 2026Observational
- A distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle-based mRNA vaccines.Science advances · 2026Article
- Pulmonary mRNA-LNP vaccines for rapid and durable protection against bacterial infection.Nature communications · 2026Article
- Highlights of 2025: advances in germinal centers.Immunology and cell biology · 2026Review
- Programming the immunological properties of mRNA vaccines for cancer.Nature reviews. Immunology · 2026Review
- A bivalent mRNA-LNP vaccine confers broad-spectrum protection against both homologous and heterologous H5/H7 highly pathogenic avian influenza viruses in SPF chickens.Veterinary research · 2026Article
- Advancements in Immune Checkpoint-Based Immunotherapy for Triple-Negative Breast Cancer.Current issues in molecular biology · 2026Review
- Decoding Undesirable Inflammatory Responses of Nucleic Acid-Delivering Lipid Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Review
- A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines.Nature immunology · 2026Article
- Fungal glycans boost mRNA-based vaccines.Nature immunology · 2026Article
- SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.Nature communications · 2026Article
Corrections and comments
- Update of
Authors and funding
28 authors.
Diana CastañoDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Emily BettiniDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Binod KumarDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aleksey ChudnovskiyLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Anna SivDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Giulia ProttiDepartment of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
Sandra Nakadakari-HigaLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Simona CegliaDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Nina De LunaDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Joy E ChiuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Katlyn LedererInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Shuk Hang LiDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hassaan IbrahimDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Hiromi MuramatsuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Thandiswa MdluliDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Edit AbrahamSynthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary; National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, Hungary.
Sinem E SahingurDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ivan MaillardInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ying K TamAcuitas Therapeutics, Vancouver, BC, Canada.
Sunny ShinDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Scott E HensleyDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jonathan J MinerInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Rheumatology, Department of Medicine, RVCL Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zoltan LipinszkiSynthetic and Systems Biology Unit, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary; National Laboratory for Biotechnology, Institute of Genetics, HUN-REN Biological Research Centre, Szeged, Hungary; ATGandCo Biotechnology Ltd, Mórahalom, Hungary.
Andrea ReboldiDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Norbert PardiDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Roberto SpreaficoInstitute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA.
Gabriel D VictoraLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA.
Michela LocciDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: michela.locci@pennmedicine.upenn.edu.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MNIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00015 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HENSLEY, SCOTT · 2021 to 2025
$50.7MTranslational Immunology CoreU19AI181968 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI FELGNER, PHILIP LOUIS · 2024 to 2024
$33.1MProject 4: Computational panbetaCoV immunogen designP01AI158571 · NIAID · DUKE UNIVERSITY · PI HENDERSON, RORY · 2021 to 2023
$28.0MNotch Signaling in AlloimmunityR01AI091627 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI PEAR, WARREN S · 2011 to 2025
$6.0MQuantifying Cell-Cell Interactions in the Immune System by Trans-Synaptic LabelingDP1AI144248 · NIAID · ROCKEFELLER UNIVERSITY · PI VICTORA, GABRIEL D · 2018 to 2022
$5.9MMechanisms of STING-associated immunodeficiencyR01AI143982 · NIAID · WASHINGTON UNIVERSITY · PI Jonathan J Miner · 2019 to 2026
$4.6MTraining in Emerging Infectious DiseasesT32AI055400 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, HENSLEY, SCOTT ERIC · 2003 to 2022
$4.4MLipid nanoparticles as novel adjuvants inducing effective T follicular helper cell and humoral immune responsesR01AI153064 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michela Locci, Norbert Pardi · 2020 to 2026
$4.2MImmune System Development and RegulationT32AI055428 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M, OLIVER, PAULA MARIA · 2003 to 2025
$4.2MDefining the role of T cell help in germinal centers by intercellular enzymatic labelingR01AI173086 · NIAID · ROCKEFELLER UNIVERSITY · PI Gabriel D Victora · 2022 to 2026
$4.0MCholesterol metabolites coordinate skin barrier immunity centered on innate dermal gammadelta T cells programmed to produce IL-17R01AI158832 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Joonsoo Kang, Andrea Reboldi · 2022 to 2026
$3.5MHoward Hughes Medical InstituteNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA278976NIAID NIH HHS 75N93021C00015NIAID NIH HHS DP1 AI144248NIAID NIH HHS P01 AI158571NIAID NIH HHS R01 AI091627NIAID NIH HHS R01 AI143982NIAID NIH HHS R01 AI146101NIAID NIH HHS R01 AI153064NIAID NIH HHS R01 AI155727NIAID NIH HHS R01 AI158832NIAID NIH HHS R01 AI168312NIAID NIH HHS R01 AI173086NIAID NIH HHS T32 AI055400NIAID NIH HHS T32 AI055428NIAID NIH HHS U19 AI181968NINDS NIH HHS R01 NS131480
Abstract
Nucleoside-modified messenger RNA (mRNA) vaccines elicit protective antibodies through their ability to promote T follicular helper (Tfh) cell differentiation. The lipid nanoparticles (LNPs) of mRNA vaccines possess inherent adjuvant activity. However, the extent to which the nucleoside-modified mRNA is sensed and contributes to Tfh cell responses remains undefined. Herein, we deconvolute the signals induced by LNPs and mRNA that instruct dendritic cells (DCs) to promote Tfh cell differentiation. We demonstrate that the mRNA drives the production of type I interferons, which act on DCs to enhance their maturation and Tfh cell differentiation, and favors plasma cells and memory B cell responses. In parallel, LNPs, which allow for mRNA uptake by DCs within the draining lymph node, also modulate Tfh cell responses by shaping the localization of CD25
Indexed as
Germinal CentermRNA VaccinesRNA, MessengerAnimalsB-LymphocytesCell DifferentiationDendritic CellsFemaleInterferon Type ILiposomesLymph NodesMemory B CellsMiceMice, Inbred C57BLNanoparticlesPlasma CellsInterferon Type ILipid NanoparticlesLiposomesmRNA VaccinesRNA, MessengerB cellsdendritic cellsgerminal centersinterferonsinterleukin-1lipid nanoparticlesmRNA vaccinesnucleoside-modified RNATfh cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.