Evidence map›Paper›PMID 41406941›Full record

ArticleCell reports. Medicine2025

Intracranial injection of genetically modified, mosquito non-transmissible Zika virus: Safety in primates and ramifications for brain tumor therapy.

Alec J Hirsch, Amanda de Andrade Costa, Cody German, Christopher J Parkins, Jessica L Smith, Emilie Russler-Germain, Ashwani Kesarwani, Yuping Li, Verginia Cuzon Carlson, Timothy Carlson and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alec J HirschThe Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
Amanda de Andrade CostaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Cody GermanThe Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
Christopher J ParkinsThe Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
Jessica L SmithThe Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA; Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
Emilie Russler-GermainDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Ashwani KesarwaniDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Yuping LiDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Verginia Cuzon CarlsonDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
Timothy CarlsonDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
Jodi L McBrideDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
Sathya SrinivasanThe Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, Beaverton, OR, USA; Imaging and Morphology Support Core at the Oregon National Primate Research Center, Beaverton, OR, USA.
Anne D LewisDivision of Comparative Medicine, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, OR, USA.
Xuping XieDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Pei-Yong ShiDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Michael S DiamondDepartments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Milan G ChhedaDivision of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mchheda@wustl.edu.

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
MOLECULAR ONCOLOGY TRAINING GRANTT32CA113275 · NCI · WASHINGTON UNIVERSITY · PI Matthew J Walter · 2006 to 2026
$5.7M
NCI NIH HHS T32 CA113275NIH HHS P51 OD011092
6 · The paper itself

Abstract

Glioblastomas (GBMs) are incurable brain tumors. Zika virus (ZIKV) has specificity in killing GBM stem cells, which drive treatment resistance. In mouse models of GBM, ZIKV also generates an anti-tumor inflammatory response and prolongs survival. To support clinical development and address safety concerns for intra-tumoral treatment, we assessed the effects of injection of an immune-sensitized ZIKV (Δ10 3'-UTR ZIKV), which cannot be transmitted by mosquitos, into non-tumor-bearing rhesus macaque brains. After injection, the primates showed no clinical signs of illness. Histologically, as expected, ZIKV infection elicited mild inflammation, which resolved within 2 weeks. No infectious virus was detected in the brain or any organs at 14 dpi. These findings, along with our preclinical observations, support the development of immune-sensitized ZIKV as a treatment for GBM.

Indexed as

Brain NeoplasmsGlioblastomaZika VirusAnimalsBrainCulicidaeDisease Models, AnimalFemaleHumansMacaca mulattaZika Virus Infectionglioblastomaoncolytic virusrhesus macaqueZika virus

Identifiers

PMID41406941
PMCPMC12765944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.