ReviewCurrent opinion in immunology2026
Indole sensing in host, microbiota, and pathogen interactions.
Review in Current opinion in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Indole is an abundant metabolite in the mammalian gut. Both mammals and microorganisms sense it. Indole is a signal used to communicate and gauge the gut environment. Indole is produced by bacteria that encode the tryptophanase enzyme. However, indole sensing is not limited to the organisms that produce it; mammals, as well as microbes incapable of producing this molecule, have receptors for it. Indole signaling has varying activities, from contributing to intestinal barrier integrity, modifying brain signaling, and preventing aging. In microorganisms, it represses biofilm formation and modulates the virulence of enteric pathogens, among other phenotypes. Although there is a renaissance in indole research, comprehensive knowledge of its signaling pathways is limited. Here, we review indole signaling across species and kingdoms. By understanding the integration of the activity of indole at the host, microbiota, and pathogen interface, one may be able to develop novel dietary and therapeutic approaches.
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