In one paragraphArticle in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Kyle ScrantonDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-6881-708X Scott JohnDivision of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-1232-9140 Marina AngeliniDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4621-3784 Andreas SchwingshacklDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5608-0199 Joshua I GoldhaberDepartment of Cardiology, Cedars-Sinai Health Sciences University, Los Angeles, CA, USA.ORCID 0000-0001-8413-5719 Riccardo OlceseDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4225-9814 Michela OttoliaDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5114-8887 Funding
Regulation of cellular calcium by cardiac sodium-calcium exchangeR01HL147569 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI GOLDHABER, JOSHUA I, OTTOLIA, MICHELA · 2019 to 2022
$2.6MSodium Dependent Inactivation of the Na+-Ca2+ exchange: Relevance to Cardiac FunctionR01HL152296 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO, OTTOLIA, MICHELA · 2021 to 2024
$2.2MThe Molecular Transitions that Initiate EC Coupling in Skeletal MuscleR35GM131896 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO · 2019 to 2023
$2.0MThe Cardiac Na-Ca exchanger: Defining the mechanisms of its operation and regulationR01HL130308 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OTTOLIA, MICHELA · 2016 to 2019
$1.6MNHLBI NIH HHS R01 HL130308NHLBI NIH HHS R01 HL147569NHLBI NIH HHS R01 HL152296NIGMS NIH HHS R35 GM131896
6 · The paper itselfAbstract
For more than two centuries, digoxin has been used to treat heart failure by increasing the strength of cardiac contraction and, more recently, is used for heart rate control. The proposed, yet unproven, mechanism underlying digoxin's positive inotropic effect is as follows: By inhibiting the Na
Indexed as
Cardiotonic AgentsDigoxinSodiumSodium-Calcium ExchangerAllosteric RegulationAnimalsCalciumHumansMyocardial ContractionMyocytes, CardiacSodium-Potassium-Exchanging ATPaseCalciumCardiotonic AgentsDigoxinSodiumSodium-Calcium Exchangersodium-calcium exchanger 1Sodium-Potassium-Exchanging ATPase
Identifiers
PMID41406234
PMCPMC12710698
What OpenQuestion holds
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