Evidence map›Paper›PMID 41406207›Full record

ArticleScience advances2025

A plant NLR receptor activates auxin signaling through Aux/IAAs-ARF19 and YUC8-TIR1/AFBs to promote callose-mediated antiviral defense.

Tongqing Yang, Ruizhen Zhao, Ruoxin Mei, Hongmin Cui, Zixuan Ding, Yanan Wen, Qian Wu, Zhengqiang Chen, Shen Huang, Chunli Wang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tongqing YangState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0003-0204-507X
Ruizhen ZhaoState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Ruoxin MeiState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Hongmin CuiState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Zixuan DingState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Yanan WenState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Qian WuInner Mongolia Potato Engineering and Technology Research Center, Inner Mongolia University, Hohhot 010021, China.
Zhengqiang ChenKey Laboratory of Biohazard Monitoring, Green Prevention and Control for Artificial Grassland, Ministry of Agriculture and Rural Affairs, Institute of Grassland Research of Chinese Academy of Agricultural Sciences, Hohhot 010010, China.
Shen HuangState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Chunli WangState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Lu HongState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Wenyu ZuoState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Zhongkai ZhangYunnan Provincial Key Laboratory of Agri-Biotechnology, Institute of Biotechnology and Genetic Resources, Yunnan Academy of Agricultural Sciences, Kunming 650223, China.
Min ZhuState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-9354-4300
Leiyun YangState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Zhengguang ZhangState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.
Suomeng DongState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-9623-6776
Yi XuState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-1913-4530
Xiaorong TaoState Key Laboratory of Agricultural and Forestry Biosecurity, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0003-1259-366X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytohormone signaling pathways are crucial for defense against pathogens mediated by pattern recognition receptors and nucleotide-binding leucine-rich repeat (NLR) immune receptors. The induction of auxin signaling by immune receptors for antiviral immunity is poorly understood despite its notable role in plant defense against viral pathogens. Here, we report that plant NLR Sw-5b initiates and amplifies auxin signaling through auxin/indole-3-acetic acid (Aux/IAAs)-ARF19 and YUC8-transport inhibitor response1/auxin-signaling F-box (TIR1/AFB) modules to promote callose-mediated antiviral defense. Upon recognizing viral effector, Sw-5b associates with and relieves repressors Aux/IAAs on transcription factor ARF19. ARF19 then activates callose synthase gene

Indexed as

ArabidopsisArabidopsis ProteinsGlucansIndoleacetic AcidsNLR ProteinsSignal TransductionTranscription FactorsF-Box ProteinsGene Expression Regulation, PlantGlucosyltransferasesPlant DiseasesPlant ImmunityReceptors, Cell SurfaceArabidopsis ProteinsARF19 protein, ArabidopsiscalloseF-Box ProteinsGlucansGlucosyltransferasesIndoleacetic AcidsNLR ProteinsReceptors, Cell SurfaceTIR1 protein, ArabidopsisTranscription Factors

Identifiers

PMID41406207
PMCPMC12710714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.