Evidence map›Paper›PMID 41406204›Full record

ArticleScience advances2025

Neurexin regulates mechanical nociceptive sensitization by central inhibition in

Zhu Meng, Junhua Geng, Yichen Sun, Lizhong Xu, Yu Zhao, Mengzhu Ou, Yuedong Wang, Junhai Han, Pengyu Gu, Wei Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhu MengKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.ORCID 0009-0004-0647-3615
Junhua GengKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.
Yichen SunState Key Laboratory of Tree Genetics and Breeding, College of Life Sciences, Nanjing Forestry University, Nanjing 210037, China.ORCID 0000-0003-1732-5955
Lizhong XuKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.
Yu ZhaoKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.
Mengzhu OuKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.
Yuedong WangDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.ORCID 0009-0003-7482-1872
Junhai HanKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.ORCID 0000-0001-8941-2578
Pengyu GuDepartment of Urology and Andrology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.ORCID 0000-0003-2571-3579
Wei XieKey Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China.ORCID 0000-0002-9179-4787

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synaptic adhesion molecules play a crucial role in shaping neural circuits and behavior, yet their contribution to nociceptive processing remains poorly understood. Here, we investigate how the synaptic organizer Neurexin regulates mechanical nociception in

Indexed as

Cell Adhesion Molecules, NeuronalDrosophilaDrosophila melanogasterDrosophila ProteinsNociceptionAnimalsCholinergic NeuronsLarvaReceptors, GABA-BCell Adhesion Molecules, NeuronalDrosophila ProteinsNrx protein, DrosophilaReceptors, GABA-B

Identifiers

PMID41406204
PMCPMC12710721

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.