Evidence map›Paper›PMID 41406145›Full record

ArticlePloS one2025

Lack of association between loneliness, social isolation and inflammation in people living with HIV aged ≥50 years: Results from the sub-study "No One Alone-Gesida Study".

Jose-Ramon Blanco, Helena Albendin-Iglesias, Eugenia Negredo-Puigmal, Ana Mª Barrios-Blandino, Cristina Tomás-Jimenez, Isabel Sanjoaquin-Conde, María Saumoy, Verónica Pérez-Esquerdo, Inmaculada Gonzalez-Cuello, Ana María López-Lirola and 22 more

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Jose-Ramon BlancoHospital Universitario San Pedro, Logroño, Spain.ORCID https://orcid.org/0000-0002-4268-0150
Helena Albendin-IglesiasHospital Virgen de la Arrixaca, Murcia, Spain.
Eugenia Negredo-PuigmalHospital Universitari Germans Trias i Pujol, Badalona, Spain.
Ana Mª Barrios-BlandinoHospital Universitario de La Princesa, Madrid - Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
Cristina Tomás-JimenezHospital General Universitario Reina Sofía, Murcia, Spain.
Isabel Sanjoaquin-CondeHospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.ORCID https://orcid.org/0000-0001-5239-7562
María SaumoyHospital Universitari de Bellvitge, L´Hospitalet de Llobregat, Spain.
Verónica Pérez-EsquerdoInstituto de Investigación Sanitaria y Biomédica de Alicante, Alicante, Spain.
Inmaculada Gonzalez-CuelloHospital Vega Baja Orihuela, Alicante, Spain.
Ana María López-LirolaHospital Universitario de Canarias, Canarias, Spain.ORCID https://orcid.org/0009-0002-6530-0103
María José GalindoHospital Clínico de Valencia, Valencia, Spain.ORCID https://orcid.org/0000-0002-4911-4071
Noemí Cabello-ClotetHospital Clínico San Carlos, Madrid, Spain.
Jesica Abadía OteroHospital Rio Hortega, Valladolid, Spain.
Dolores Merino-MuñozHospital Juan Ramón Jiménez, Huelva, Spain.
Joanna Cano-SmithHospital Universitario La Paz, Madrid, Spain.
Magdalena Muelas-FernandezHospital de Viladecans, Viladecans, Spain.
Javier De La TorreHospital Costa del Sol, Marbella, Spain.ORCID https://orcid.org/0000-0003-4718-0320
Alicia González-BaezaUniversidad Autónoma de Madrid, Madrid, Spain.
Lourdes RomeroCentro de Investigación Biomédico de La Rioja, Logroño, Spain.
Antonio OcampoHospital Álvaro Cunqueiro, Vigo, Spain.
Rafael TorresHospital Severo Ochoa, Leganes, Spain.
Carmen HidalgoHospital Virgen de las Nieves, Granada, Spain.ORCID https://orcid.org/0000-0002-6394-5728
Herminia EstebanFundación SEIMC-GESIDA, Madrid, Spain.
Maria Angeles Fernandes-LópezHospital Virgen de la Arrixaca, Murcia, Spain.
Jordi PuigHospital Universitari Germans Trias i Pujol, Badalona, Spain.
Lucio Garcia FraileHospital Universitario de La Princesa, Madrid - Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.
Enrique Bernal MorellHospital General Universitario Reina Sofía, Murcia, Spain.
Laura Perez-MartinezCentro de Investigación Biomédico de La Rioja, Logroño, Spain.
Marta De Miguel MonteroFundación SEIMC-GESIDA, Madrid, Spain.
Inma JarrinNational Center for Epidemiology, Institute of Health Carlos III (ISCIII), Madrid, Spain. Center of Biomedical Research for Infectious Diseases (CIBERINFEC), Institute of Health Carlos III (ISCIII), Madrid, Grupo de Estudio Gesida, Spain.
Julian OlallaHospital Costa del Sol, Marbella, Spain.
GESIDA 12021 STUDY GROUP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation - loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic inflammation even with viral suppression, likely due to ongoing immune activation. However, few studies have explored inflammatory biomarker in PLWH experiencing loneliness or social isolation. This study aimed to assess this association in PLWH aged 50 or older.

Indexed as

HIV InfectionsInflammationLonelinessSocial IsolationAgedBiomarkersFemaleHumansMaleMiddle AgedBiomarkers

Identifiers

PMID41406145
PMCPMC12711021

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.