Evidence map›Paper›PMID 41406055›Full record

ReviewNephron2025

Bench to Bedside: Translating Discoveries to Clinical Care in Kidney Disease.

Katharine Epler, Dana Y Fuhrman, Sudarshan Hebbar, Volker Vallon, Mark Hepokoski

Abstract readReview
In one paragraph

Review in Nephron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katharine EplerUCSD and VA San Diego Healthcare System, San Diego, California, USA.
Dana Y FuhrmanUPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sudarshan HebbarCalciMedica, Inc., San Diego, California, USA.
Volker VallonUCSD and VA San Diego Healthcare System, San Diego, California, USA.
Mark HepokoskiUCSD and VA San Diego Healthcare System, San Diego, California, USA, mhepokoski@health.ucsd.edu.

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
UAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PAUL W. SANDERS · 2023 to 2026
$4.4M
Deep South KUH Premier Research - Interdisciplinary Mentored Education (PRIME) Training CoreTL1DK139566 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID M POLLOCK · 2023 to 2026
$3.6M
Deep South KUH Premier Research- Interdisciplinary Mentored Education (PRIME) Networking CoreU2CDK133422 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kelly Hyndman · 2023 to 2026
$2.8M
BLRD VA I01 BX006238NIDDK NIH HHS P30 DK079337NIDDK NIH HHS TL1 DK139566NIDDK NIH HHS U2C DK133422NIDDK NIH HHS U54 DK137307
6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) pathophysiology and repair are heterogenous processes, and clinical outcomes are difficult to predict. As a result, promising treatments in preclinical models have failed to translate to human subjects, and treatment options for AKI are primarily supportive. SUMMARY: To address this, one of the AKI and CRRT 2025 preconference symposium plenary sessions showcased cutting-edge translational work to guide the scientific community of AKI investigators. Topics included those focused on stratifying risk for AKI reflected in the concept of kidney fitness, characterizing the molecular phenotypes of AKI, improving diagnostics, and identifying novel therapeutic targets. KEY MESSAGES: This article provides a review of these topics and a summary of how they address challenges to translating new therapies in AKI from bench to bedside.

Indexed as

KidneyPhenotypeTranslation

Identifiers

PMID41406055
PMCPMC13095146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.