Evidence map›Paper›PMID 41406017›Full record

ArticleeLife2025

Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development.

Juanjuan Zhao, Susann Bruche, Konstantinos Lekkos, Carolyn Carr, Joaquim Miguel Vieira, John Parnavelas, William D Andrews, Mathilda Mommersteeg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juanjuan ZhaoDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Susann BrucheDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-5814-7166
Konstantinos LekkosDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-5044-2876
Carolyn CarrDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Joaquim Miguel VieiraSchool of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine, Kings College London, British Heart Foundation Centre - James Black Centre, London, United Kingdom.ORCID https://orcid.org/0000-0003-2023-6304
John ParnavelasDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
William D AndrewsDepartment of Cell and Developmental Biology, University College London, London, United Kingdom.
Mathilda MommersteegDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-6624-3038

Funding

Biotechnology and Biological Sciences Research Council BB/W015277/1British Heart Foundation FS/19/31/34158British Heart Foundation PG/15/50/31594British Heart Foundation RE/18/3/34214European Molecular Biology Organization ALTF 441-2010European Research Council 715895European Research Council CAVEHEARTMedical Research Council MR/W006731/1ZonMw 825.10.025
6 · The paper itself

Abstract

Axon guidance cues direct nerves in the heart during development, disease, and regeneration. These cues determine cardiac innervation patterning by regulating the balance between chemo-attraction and chemo-repulsion. However, the role of one of the most crucial ligand-receptor combinations among axon guidance molecules, the Slit chemo-active ligands and their Roundabout (Robo) transmembrane receptors, remains unknown during cardiac innervation patterning. To test if Slit-Robo signalling is important for cardiac innervation guidance, we analysed Slit and Robo mouse knock-outs. Constitutive

Indexed as

HeartIntercellular Signaling Peptides and ProteinsNerve Tissue ProteinsReceptors, ImmunologicSympathetic Nervous SystemAnimalsAxon GuidanceMembrane ProteinsMiceMice, KnockoutRoundabout ProteinsSlit Homolog 2 ProteinIntercellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsReceptors, ImmunologicRobo2 protein, mouseRoundabout ProteinsSlit3 protein, mouseSlit Homolog 2 Proteindevelopmental biologyheart developmentinnervationmouseroboslit

Identifiers

PMID41406017
PMCPMC12711195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.