Evidence map›Paper›PMID 41405861›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Crucial roles of mesenchymal

Allyssa Fogarty, Shuai Jia, Jillian Wilbourne, Claire DuPuis, Fei Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Crucial roles of mesenchymalProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Allyssa FogartyDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-9962-9073
Shuai JiaDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-1371-243X
Jillian WilbourneDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.
Claire DuPuisDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0009-0004-2936-7276
Fei ZhaoDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-3107-1576

Funding

Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Mechanisms of androgen-dependent Wolffian duct differentiationR01HD111425 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Fei Zhao · 2023 to 2026
$1.7M
Unexpected roles of the male tract mesenchyme in female reproductive tract formationR00HD096051 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ZHAO, FEI · 2020 to 2022
$727k
HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R00HD096051HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD111425NICHD NIH HHS P50 HD105353NICHD NIH HHS R00 HD096051NICHD NIH HHS R01 HD111425
6 · The paper itself

Abstract

Androgens drive the morphogenesis and differentiation of the Wolffian duct (WD) into the epididymis, an essential organ for male reproduction, by binding to the androgen receptor (AR). However, it remains unclear whether other transcriptional programs operate beyond the central androgen/AR signaling in promoting WD development. We found that mesenchyme-specific deletion of the transcription factor

Indexed as

EpididymisGATA2 Transcription FactorMesodermAndrogensAnimalsDihydrotestosteroneEmbryo, MammalianFemaleFertilityGene Expression Regulation, DevelopmentalMaleMiceMice, Inbred C57BLMice, KnockoutOrgan Culture TechniquesReceptors, AndrogenAndrogensDihydrotestosteroneGata2 protein, mouseGATA2 Transcription FactorReceptors, Androgenandrogen receptorepididymisGATA2male reproductive tractWolffian duct

Identifiers

PMID41405861
PMCPMC12745704

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.