Evidence map›Paper›PMID 41405859›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Lab on an end: Micromanipulation using the acoustohydrodynamic pillar array as an end effector.

Zhuo Chen, Chenhao Bai, Fengyu Liu, Qiang Huang, Toshio Fukuda, Tatsuo Arai, Xiaoming Liu

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Micro/Nanoscale Acoustic Manipulation: From Particle Control to Autonomous Microswimmers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhuo Chen *Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China.ORCID 0000-0003-1597-9058
Chenhao Bai *Key Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China.
Fengyu LiuKey Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China.
Qiang HuangKey Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China.
Toshio FukudaInstitute of Innovation for Future Society, Nagoya University, Nagoya 4648601, Japan.
Tatsuo AraiKey Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China.
Xiaoming LiuKey Laboratory of Biomimetic Robots and Systems, Ministry of Education, State Key Laboratory of Intelligent Control and Decision of Complex System, and School of Mechatronics Engineering, Beijing Institute of Technology, Beijing 100081, China.ORCID 0000-0003-0230-2742

Funding

åŒ-京å¸'ç§'å¦æŠ€æœ¯å§"å'˜ä¼š | Natural Science Foundation of Beijing Municipality (åŒ-京å¸'自ç¶ç§'å¦åŸºé‡') IS23062åŒ-京å¸'ç§'å¦æŠ€æœ¯å§"å'˜ä¼š | Natural Science Foundation of Beijing Municipality (åŒ-京å¸'自ç¶ç§'å¦åŸºé‡') L248102Ministry of Education, Culture, Sports, Science and Technology (MEXT) 23K22712MOST | National Natural Science Foundation of China (NSFC) 62273052MOST | National Natural Science Foundation of China (NSFC) W2431050
6 · The paper itself

Abstract

The concept of microfluidics has shown considerable promise for advancing chemistry, diagnostics, and biology. However, there have been no guaranteed routes of microfluidics that can achieve widespread adoption in mainstream chemistry and biomedical research. Inspired by the cooperative multiple cilia of biological organisms and tissues to generate flow, we propose an open microfluidic platform, lab on an end (LoE), to pump spatially and temporally continuous flow for multifunctional micromanipulation with the acoustohydrodynamic pillar array as an end effector. LoE brings together the micromanipulation of individual entities, liquid operations, and cell processing onto an acoustic end effector. These operations are mainly driven by acoustic radiation and two unique frequency-dependent microstreaming profiles: out-of-plane vortex near a single pillar and in-plane transmission flow surrounding the entire pillar array. Applications in embryo engineering, local morphological phenotyping of

Indexed as

AcousticsLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesMicrofluidicsMicromanipulationAnimalsCaenorhabditis elegansacoustohydrodynamicsdroplet manipulationmicromanipulationopen microfluidic devicessingle-cell operation

Identifiers

PMID41405859
PMCPMC12745804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.