ArticleInsights into imaging2025
Early-phase semi-quantitative analysis versus full time-course quantitative modeling of ultrafast dynamic contrast-enhanced MRI for breast cancer diagnosis, molecular subtyping, and treatment response prediction.
Article in Insights into imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
objectivesTo evaluate the performance of semi-quantitative analysis versus quantitative pharmacokinetic analysis applied to ultrafast dynamic contrast-enhanced (UF-DCE) MRI in: (1) differentiating benign from malignant breast lesions, (2) molecular subtyping, and (3) predicting pathologic complete response (pCR) following neoadjuvant chemotherapy. MATERIALS AND
methodsThis prospective noninferiority study enrolled 339 consecutive participants with suspected breast lesions between September 2022 and February 2024. All underwent breast DCE MRI with a temporal resolution of 4.5 s, totaling 100 phases. Using the initial 30 phases (early-phase UF-DCE), five semi-quantitative parameters were calculated: wash-in slope (WIS), time-to-peak, bolus arrival time, peak enhancement intensity (PEI), and initial area under the curve in 60 s. Furthermore, three quantitative parameters: volume transfer constant, rate constant (k
resultsAll semi-quantitative and quantitative parameters showed differences between benign and malignant breast lesions (p < 0.001). Semi-quantitative WIS demonstrated noninferior diagnostic performance to quantitative k
conclusionSemi-quantitative analysis of early-phase UF-DCE exhibits noninferior performance to quantitative analysis of full time-course UF-DCE MRI for distinguishing benign from malignant breast lesions. Both analytical approaches showed limited utility in molecular subtyping and pCR prediction. CRITICAL RELEVANCE STATEMENT: Early-phase UF-DCE MRI provides a cost-effective alternative to full time-course UF-DCE MRI for differentiating benign and malignant breast lesions, demonstrating noninferior diagnostic performance with reduced scan time and no need for pharmacokinetic modeling. KEY POINTS: Systematic comparison of early-phase UF-DCE and full time-course UF-DCE MRI for diagnosis, subtyping, and response prediction in a single breast cancer cohort remains limited. Early-phase UF-DCE MRI demonstrated noninferior diagnostic performance to full time-course UF-DCE MRI in differentiating benign and malignant breast lesions. Early-phase UF-DCE MRI is a time-efficient alternative to full time-course UF-DCE MRI for clinical implementation.
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