ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Impact of arterial occlusion location on early neurological deterioration in patients with minor stroke treated with intravenous thrombolysis. The MINORCAT-END study.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Beyond the total NIHSS score: association between impaired level of consciousness and early neurological deterioration in mild large vessel occlusion stroke.Neuroradiology · 2026Article
- Endovascular treatment and clinical outcomes in minor ischemic stroke due to large-vessel disease: a retrospective study.Frontiers in neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors.
Funding
Abstract
purposeTo assess the proportion of early neurological deterioration (END) in patients with minor stroke, its impact on 3-month clinical outcomes, and the influence of large vessel occlusion (LVO) location on END development.
methodsWe analyzed patients from the CICAT Code Stroke Registry in Catalonia, Spain, between January 1, 2016, and December 31, 2021. Inclusion criteria were baseline NIHSS ≤ 5, treatment with intravenous thrombolysis (IVT) with or without endovascular treatment (EVT), and available acute vascular imaging. END was defined as an NIHSS increase of ≥ 4 points at 24-36 h post-treatment. Poor clinical outcome was defined as modified Rankin Scale (mRS) 3-6 at 3 months.
findingsA total of 1,380 patients were included (median age 71 [IQR 59-79] years; 59% male; median NIHSS 4 [IQR 3-5]). LVO was present in 282 patients (20.4%). END occurred in 73 patients (5.3%): 12.1% with LVO vs. 3.6% without LVO (p < 0.001). LVO was the strongest predictor of END (OR 3.73; 95% CI 2.30-6.06; p < 0.001), regardless of occlusion level. Poor 3-month outcome was observed in 74% of patients with END, compared to 26.8% without END (p < 0.001). END independently predicted poor outcome (OR 6.79; 95% CI 3.23-14.31).
conclusionsIn minor stroke patients treated with IVT or IVT + EVT, LVO was the primary driver of END even for mediun-sized arteries. END emerged as the strongest predictor of poor 3-month functional outcome.
Indexed as
Identifiers
41405770What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.