Evidence map›Paper›PMID 41405752›Full record

SynthesisAIDS and behavior2026

The Association Between Different Levels of Suppressed Viral Load and the Risk of Sexual Transmission of HIV Among Serodiscordant Couples on Antiretroviral Therapy: A Systematic Review.

Pascal Djiadeu, Housne Begum, Michelle Haavaldsrud, Giovanna Busa, Jeffery Dansoh, Phu Van Nguyen, Taline Ekmekjian, Annie Fleurant, Stephan Gadient, Chris Archibald

Abstract readSystematic Review
In one paragraph

Synthesis in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pascal DjiadeuSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada.ORCID http://orcid.org/0000-0001-9708-6530
Housne BegumSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada.ORCID http://orcid.org/0000-0003-1561-9423
Michelle HaavaldsrudSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada. michelle.haavaldsrud@phac-aspc.gc.ca.ORCID http://orcid.org/0009-0004-8378-9082
Giovanna BusaSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada.ORCID http://orcid.org/0009-0003-2173-488X
Jeffery DansohSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada.ORCID http://orcid.org/0009-0002-6022-4455
Phu Van NguyenSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada.ORCID http://orcid.org/0009-0002-0462-4040
Taline EkmekjianPHAC Library, Public Health Agency of Canada, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0002-0914-0056
Annie FleurantSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada.ORCID http://orcid.org/0009-0003-6185-7227
Stephan GadientSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada.ORCID http://orcid.org/0009-0004-4703-7131
Chris ArchibaldSexually Transmitted and Blood Borne Infections Surveillance Division, Centre for Communicable Diseases and Infection Control, Infectious Diseases and Vaccination Programs Branch, Public Health Agency of Canada, 130 Colonnade Rd., Ottawa, ON, K1A 0K9, Canada.ORCID http://orcid.org/0009-0000-9460-980X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of sexual transmission of HIV in serodiscordant couples when the partner living with HIV (PLHIV) uses antiretroviral therapy (ART) and maintains a suppressed viral load (VL) (< 200 copies/mL) is estimated at 0.00 transmissions per 100 person-years (95% CI 0.00-0.10). A recent review reported an almost zero transmission risk for VL < 1000 copies/mL but lacked quantitative risk estimates. This systematic review aimed to quantify transmission risk across VL levels. A literature search (November 2023, updated January 2025) identified 152 studies, with 9 included in the analysis. Seven possible transmissions occurred when the PLHIV had a VL of < 1000 copies/mL at the last measurement before the estimated time of transmission. However, VL at the exact time of transmission was unknown and VL > 1000 copies/mL cannot be excluded. This review suggests sexual transmission is very rare with recent VL < 1000 copies/mL however, future research is required to establish precise risk estimates.PROSPERO Number: CRD42023476946.

Indexed as

Anti-HIV AgentsAnti-Retroviral AgentsHIV InfectionsSexual PartnersViral LoadFamily CharacteristicsFemaleHumansMaleRisk FactorsAnti-HIV AgentsAnti-Retroviral Agents< 1000 copies/mLAntiretroviralsEpidemiologyHIV and AIDSHIV transmissionPublic healthSerodiscordant couplesSexually transmitted diseasesSystematic reviewViral load suppression

Identifiers

PMID41405752
PMCPMC13167889

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.