ArticleAnnals of biomedical engineering2026
Optimization of Bone Cement Stiffness in Metastatic Vertebral Augmentation: Balancing Strength Restoration and Stress Redistribution.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A Viscoelastic Modeling for Failure Analysis of Human Vertebral Bone Undergoing Quasi-Static and Dynamic Compression.Bioengineering (Basel, Switzerland) · 2026Article
- A mechanobiological hypothesis on bone cement-induced progression of bone metastases.Frontiers in bioengineering and biotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeThe goal of this study was to investigate the mechanical performance of vertebral augmentation with various polymer-based materials across different defect sizes. Specifically, this study aimed to identify the optimal stiffness of bone cement that maximizes vertebral strength while minimizing stress redistribution.
methodA calibrated quantitative computed tomography-based finite element analysis (QCT/FEA) approach was developed and calibrated against cadaveric experimental data. Lytic metastatic defects were simulated in human vertebrae at two augmentation volumes (20 and 50%) and filled with materials spanning a wide range of elastic moduli (50 to 2500 MPa). Stress distributions and fracture forces were analyzed in six vertebrae to evaluate the influence of material stiffness and augmentation size.
resultsThe QCT/FEA models accurately predicted vertebral strength (R
conclusionsThe findings suggest that a bone cement stiffness of approximately 300 MPa may provide optimal mechanical benefits by enhancing vertebral strength without inducing excessive stress redistribution. The study also highlights that augmentation size strongly influences the mechanical outcomes, with larger augmentation volumes showing greater sensitivity to material stiffness. The proposed patient-specific QCT/FEA framework provides a cost-efficient, adaptable tool for preclinical evaluation and personalized planning of vertebral augmentation These insights can assist material developers in optimizing bone cement formulations for patient-specific treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.