Trial reportWorld journal of urology2025
Randomized trial of thulium laser-assisted tumor bed coagulation versus conventional suture renorrhaphy in laparoscopic partial nephrectomy: impact on perioperative outcomes and fibrosis biomarker response.
Trial report in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322745 (Thulium Beam Coagulation Versus Suture Renorrhaphy for Hemostasis of Tumor Bed in Laparoscopic Partial Nephrectomy), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thulium Beam Coagulation Versus Suture Renorrhaphy for Hemostasis of Tumor Bed in Laparoscopic Partial Nephrectomy: Prospective Randomized Comparative Study
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to determine whether thulium laser–assisted tumor bed hemostasis could provide effective bleeding control comparable to conventional suture renorrhaphy while minimizing ischemic exposure, parenchymal trauma, and profibrotic response. Specifically, we compared perioperative outcomes, renal functional preservation, and urinary fibrosis biomarker profiles between the two techniques during laparoscopic partial nephrectomy (LPN).
methodsIn this prospective randomized trial (March 2024–September 2025), 48 patients with clinical T1 renal masses and a normal contralateral kidney were assigned to thulium laser-assisted LPN (LLPN) or conventional LPN (CLPN). In LLPN, tumor bed hemostasis was achieved with a 2-μm continuous thulium laser followed by cortical closure, while CLPN employed standard medullary and cortical renorrhaphy. Perioperative outcomes, renal function (estimated glomerular filtration rate, eGFR), and urinary fibrosis biomarkers (transforming growth factor-β1 [TGF-β1], monocyte chemoattractant protein-1 [MCP-1]) were assessed preoperatively and on postoperative day 1, and at 1 and 3 months.
resultsForty-three patients (LLPN 23, CLPN 20) were analyzed. Operative time and warm ischemia time were shorter in LLPN than CLPN (95 vs. 121 min, p = 0.001; 13 vs. 17 min, p = 0.037). LLPN required fewer sutures (8 vs. 14, p < 0.001) and resulted in lower blood loss (150 vs. 300 mL, p < 0.001). All complications were low-grade and comparable. eGFR declined significantly in both groups, with partial recovery in LLPN but not CLPN; between-group differences were not significant. Urinary TGF-β1 and MCP-1 increased postoperatively in both groups but were consistently lower in LLPN at all time points (p < 0.05).
conclusionThulium laser coagulation during LPN reduces ischemia, blood loss, and suture requirement without compromising safety or short-term renal function. The attenuated rise in fibrosis biomarkers suggests a potential long-term nephron-sparing advantage. The study was registered on ClinicalTrials.gov (Identifier: NCT06322745, registered March 14, 2024).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.